e-Drug3D

1720

cas 864070-44-0

CLASS

METABOLISM
TREATMENT OF TYPE 2 DIABETES MELLITUS
SODIUM-GLUCOSE CO-TRANSPORTER2 (SGLT2) INHIBITOR

ROUTE (list)

ORAL

PK parameters

Tmax 1.5 HOUR
VD 73.8 LITER
Cl 10.6 LITER / HOUR
PPB 86.2 PERCENT
t1/2 12.4 HOUR

TARGET SODIUM-GLUCOSE CO-TRANSPORTER2 (SGLT2)

PDB
7Y0B (CRYSTAL STRUCTURE OF HUMAN SHORT-CHAIN ACYL-COA DEHYDROGENASE)

Ligand code = 7R3 (link to the list of PDB complexes)

Download experimental 3D coordinates of 7R3 with added hydrogens

MW 450.90
NB_atoms 31
XLogP 1.61
PSA 113.055
NB_HD 4
NB_HA 7
fsp3 0.48
Lipinski(0=no;1=yes) 1

FDA
NDA 204629 (pdf not found) INN (EMPAGLIFLOZIN) JARDIANCE (BOEHRINGER INGELHEIM) APPROVAL= AP YEAR= 2014
NDA 206073 (pdf not found) INN (EMPAGLIFLOZIN ; LINAGLIPTIN) GLYXAMBI (BOEHRINGER INGELHEIM) APPROVAL= AP YEAR= 2015
NDA 206111 (pdf not found) INN (EMPAGLIFLOZIN ; METFORMIN HYDROCHLORIDE) SYNJARDY (BOEHRINGER INGELHEIM) APPROVAL= AP YEAR= 2015
NDA 208658 (pdf not found) INN (EMPAGLIFLOZIN ; METFORMIN HYDROCHLORIDE) SYNJARDY XR (BOEHRINGER INGELHEIM) APPROVAL= AP YEAR= 2016
NDA 212359 (pdf not found) INN (EMPAGLIFLOZIN ; LINAGLIPTIN) EMPAGLIFLOZIN AND LINAGLIPTIN (MSN LABS PVT LTD) APPROVAL= TA YEAR= 2020
NDA 212614 (pdf not found) INN (EMPAGLIFLOZIN ; LINAGLIPTIN ; METFORMIN HYDROCHLORIDE) TRIJARDY XR (BOEHRINGER INGELHEIM) APPROVAL= AP YEAR= 2020
NDA 212354 (pdf not found) INN (EMPAGLIFLOZIN ; LINAGLIPTIN) EMPAGLIFLOZIN; LINAGLIPTIN (KINAPSE LIMITED) APPROVAL= TA YEAR= 2020
NDA 212322 (pdf not found) INN (EMPAGLIFLOZIN) EMPAGLIFLOZIN (AIZANT) APPROVAL= TA YEAR= 2020
NDA 212364 (pdf not found) INN (EMPAGLIFLOZIN ; LINAGLIPTIN) EMPAGLIFLOZIN; LINAGLIPTIN (ANNORA PHARMA) APPROVAL= TA YEAR= 2021
NDA 212365 (pdf not found) INN (EMPAGLIFLOZIN) EMPAGLIFLOZIN (ANNORA PHARMA) APPROVAL= TA YEAR= 2021
NDA 213654 (pdf not found) INN (EMPAGLIFLOZIN ; METFORMIN HYDROCHLORIDE) EMPAGLIFLOZIN;METFORMIN HYDROCHLORIDE (LUPIN LTD) APPROVAL= TA YEAR= 2021
NDA 212198 (pdf not found) INN (EMPAGLIFLOZIN ; METFORMIN HYDROCHLORIDE) EMPAGLIFLOZIN AND METFORMIN HYDROCHLORIDE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 212264 (pdf not found) INN (EMPAGLIFLOZIN ; LINAGLIPTIN) EMPAGLIFLOZIN AND LINAGLIPTIN (PRINSTON PHARMA INC) APPROVAL= TA YEAR= 2022
NDA 212421 (pdf not found) INN (EMPAGLIFLOZIN) EMPAGLIFLOZIN (LAURUS GENERICS INC) APPROVAL= TA YEAR= 2022
NDA 212138 (pdf not found) INN (EMPAGLIFLOZIN) EMPAGLIFLOZIN (ZYDUS PHARMS) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 212366 (pdf not found) INN (EMPAGLIFLOZIN ; LINAGLIPTIN) EMPAGLIFLOZIN; LINAGLIPTIN (ALKEM LABS LTD) APPROVAL= TA YEAR= 2022
NDA 212382 (pdf not found) INN (EMPAGLIFLOZIN) EMPAGLIFLOZIN (ALKEM LABS LTD) APPROVAL= TA YEAR= 2022
NDA 212343 (pdf not found) INN (EMPAGLIFLOZIN) EMPAGLIFLOZIN (SUN PHARM INDS LTD) APPROVAL= TA YEAR= 2023
NDA 212362 (pdf not found) INN (EMPAGLIFLOZIN ; METFORMIN HYDROCHLORIDE) EMPAGLIFLOZIN METFORMIN HYDROCHLORIDE (MSN LABS PVT LTD) APPROVAL= TA YEAR= 2023
NDA 217049 (pdf not found) INN (EMPAGLIFLOZIN ; LINAGLIPTIN ; METFORMIN HYDROCHLORIDE) EMPAGLIFLOZIN; LINAGLIPTIN; METFORMIN HYDROCHLORIDE (ZYDUS PHARMS USA INC) APPROVAL= TA YEAR= 2024
NDA 212243 (pdf not found) INN (EMPAGLIFLOZIN ; METFORMIN HYDROCHLORIDE) EMPAGLIFLOZIN; METFORMIN HYDROCHLORIDE (CIPLA LTD) APPROVAL= TA YEAR= 2024
NDA 218483 (pdf not found) INN (EMPAGLIFLOZIN ; METFORMIN HYDROCHLORIDE) EMPAGLIFLOZIN; METFORMIN HYDROCHLORIDE (PRINSTON PHARMA INC) APPROVAL= TA YEAR= 2024
NDA 212373 (pdf not found) INN (EMPAGLIFLOZIN ; METFORMIN HYDROCHLORIDE) EMPAGLIFLOZIN; METFORMIN HYDROCHLORIDE (MACLEODS PHARMS LTD) APPROVAL= TA YEAR= 2025
NDA 217055 (pdf not found) INN (EMPAGLIFLOZIN) EMPAGLIFLOZIN (AJANTA PHARMA LTD) APPROVAL= TA YEAR= 2025