e-Drug3D

1719

cas 461432-26-8

CLASS

METABOLISM
A SODIUM-GLUCOSE COTRANSPORTER 2 (SGLT2) INHIBITOR
TREATMENT OF TYPE 2 DIABETES MELLITU
IMPROVE GLYCEMIC CONTROL

ROUTE (list)

ORAL

PK parameters

F 78 PERCENT
Tmax 2 HOUR
PPB 91 PERCENT
t1/2 12.9 HOUR

TARGET SODIUM-GLUCOSE COTRANSPORTER 2 (SGLT2)

PDB
8HEZ (STRUCTURE OF HUMAN SGLT2-MAP17 COMPLEX WITH DAPAGLIFLOZIN)

Ligand code = LE6 (link to the list of PDB complexes)

Download experimental 3D coordinates of LE6 with added hydrogens

MW 408.86
NB_atoms 28
XLogP 1.84
PSA 101.943
NB_HD 4
NB_HA 6
fsp3 0.43
Lipinski(0=no;1=yes) 1

FDA
NDA 202293 (label) INN (DAPAGLIFLOZIN) FARXIGA (ASTRAZENECA AB) APPROVAL= AP YEAR= 2014
NDA 205649 (label) INN (DAPAGLIFLOZIN ; METFORMIN HYDROCHLORIDE) XIGDUO XR (ASTRAZENECA AB) APPROVAL= AP YEAR= 2014
NDA 209091 (label) INN (DAPAGLIFLOZIN ; SAXAGLIPTIN HYDROCHLORIDE) QTERN (ASTRAZENECA AB) APPROVAL= AP YEAR= 2017
NDA 210874 (label) INN (DAPAGLIFLOZIN ; METFORMIN HYDROCHLORIDE ; SAXAGLIPTIN HYDROCHLORIDE) QTERNMET XR (ASTRAZENECA AB) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 211439 (pdf not found) INN (DAPAGLIFLOZIN) DAPAGLIFLOZIN (HETERO LABS UNIT III) APPROVAL= TA YEAR= 2019
NDA 211442 (pdf not found) INN (DAPAGLIFLOZIN) DAPAGLIFLOZIN (APOTEX INC) APPROVAL= TA YEAR= 2019
NDA 211541 (pdf not found) INN (DAPAGLIFLOZIN) DAPAGLIFLOZIN (TEVA PHARMS USA INC) APPROVAL= TA YEAR= 2019
NDA 211533 (pdf not found) INN (DAPAGLIFLOZIN ; SAXAGLIPTIN) DAPAGLIFLOZIN AND SAXAGLIPTIN (MSN LABS PVT LTD) APPROVAL= TA YEAR= 2020
NDA 211564 (pdf not found) INN (DAPAGLIFLOZIN) DAPAGLIFLOZIN (GLENMARK GENERICS) APPROVAL= TA YEAR= 2020
NDA 211478 (pdf not found) INN (DAPAGLIFLOZIN) DAPAGLIFLOZIN (MSN LABORATORIES PRIVATE LTD) APPROVAL= TA YEAR= 2021
NDA 211583 (pdf not found) INN (DAPAGLIFLOZIN ; METFORMIN HYDROCHLORIDE) DAPAGLIFLOZIN;METFORMIN HYDROCHLORIDE (TEVA PHARMS USA INC) APPROVAL= TA YEAR= 2022
NDA 216119 (pdf not found) INN (DAPAGLIFLOZIN) DAPAGLIFLOZIN (JIANGSU HANSOH PHARM) APPROVAL= TA YEAR= 2022
NDA 211523 (pdf not found) INN (DAPAGLIFLOZIN) DAPAGLIFLOZIN (AIZANT) APPROVAL= TA YEAR= 2023
NDA 211582 (pdf not found) INN (DAPAGLIFLOZIN) DAPAGLIFLOZIN (ZYDUS PHARMS) APPROVAL= TA YEAR= 2024
NDA 211532 (pdf not found) INN (DAPAGLIFLOZIN ; SAXAGLIPTIN MONOHYDRATE) DAPAGLIFLOZIN AND SAXAGLIPTIN MONOHYDRATE (LUPIN LTD) APPROVAL= TA YEAR= 2024
NDA 211559 (pdf not found) INN (DAPAGLIFLOZIN ; METFORMIN HYDROCHLORIDE) DAPAGLIFLOZIN AND METFORMIN HYDROCHLORIDE (MACLEODS PHARMACEUTICALS LTD) APPROVAL= TA YEAR= 2025
NDA 218091 (pdf not found) INN (DAPAGLIFLOZIN ; METFORMIN) DAPAGLIFLOZIN AND METFORMIN (SINOTHERAPEUTICS INC) APPROVAL= TA YEAR= 2025