e-Drug3D

1716

TEDIZOLID

INN
TEDIZOLID

(is an active metabolite)

cas 856866-72-3

CLASS

ANTIINFECTIVES
ANTIBACTERIAL AGENT OF THE OXAZOLIDINONE CLASS
BINDING TO THE 50S SUBUNIT OF THE BACTERIAL RIBOSOME

ROUTE (list)

ATC code

J01XX11

PK parameters

F 91 PERCENT
Tmax 1.2 HOUR
VD 73.5 LITER
Cl 5.9 LITER / HOUR
PPB 80 PERCENT
t1/2 12 HOUR

Target

TARGET RIBOSOME 50S SUBUNIT

PDB
6WRS (STRUCTURE OF THE 50S SUBUNIT OF THE RIBOSOME FROM METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS IN COMPLEX WITH THE ANTIBIOTIC, TEDIZOLID)

Ligand code = U7V (link to the list of PDB complexes)

Download experimental 3D coordinates of U7V with added hydrogens

DrugCentral

Unknown

Download SDF file

2-Oxazolidinone, 3-[3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-5-(hydroxymethyl)-, (5R)-

Formula:
C17H15FN6O3

Calculated chemical properties:

MW 370.35
NB_atoms 27
XLogP 1.40
PSA 102.521
NB_HD 1
NB_HA 9
fsp3 0.24
Lipinski(0=no;1=yes) 1

FDA
-