e-Drug3D

1692

FOSINOPRILAT

INN
FOSINOPRILAT

cas 95399-71-6

CLASS

CARDIOVASCULAR
ANGIOTENSIN-CONVERTING ENZYME INHIBITORS
ANTIHYPERTENSIVE AGENTS

ROUTE (list)

PK parameters

Tmax 3 HOUR
VD 8.45 LITER (65 KILOGRAM)
Cl 1.95 LITER / HOUR
PPB 99.4 PERCENT
t1/2 12 HOUR

Target

TARGET ANGIOTENSIN-CONVERTING ENZYME

PDB
7Z6Z (CRYSTAL STRUCTURE OF ANGIOTENSIN-1 CONVERTING ENZYME N-DOMAIN IN COMPLEX WITH FOSINOPRILAT)

Download experimental 3D coordinates of KS8 with added hydrogens

Angiotensin-converting enzyme UNIPROT P12821 ACE

Download SDF file

L-Proline, 4-cyclohexyl-1-[2-[hydroxy(4-phenylbutyl)phosphinyl]acetyl]-, (4S)-

Formula:
C23H34NO5P

Calculated chemical properties:

MW 434.47
NB_atoms 30
XLogP 2.83
PSA 95.898
NB_HD 1
NB_HA 6
fsp3 0.65
Lipinski(0=no;1=yes) 1

FDA
-