e-Drug3D

1688

FLUDARABINE

INN
FLUDARABINE

cas 21679-14-1

CLASS

ANTINEOPLASTIC
ANTIMETABOLITES
IMMUNOSUPPRESSIVE AGENTS
PHOSPHORYLATED BY DEOXYCYTIDINE KINASE TO THE ACTIVE TRIPHOSPHATE

ROUTE (list)

ATC code

L01BB05

PK parameters

F 57 PERCENT
Tmax 1.5 HOUR
VD 143 LITER (65 KILOGRAM)
Cl 12.4 LITER / HOUR (65 KILOGRAM)
PPB 24 PERCENT
t1/2 20 HOUR

Target

TARGET DEOXYCYTIDINE KINASE

DNA polymerase alpha catalytic subunit UNIPROT P09884 POLA1

Download SDF file

9H-Purin-6-amine, 9-beta-D-arabinofuranosyl-2-fluoro-

Formula:
C10H12FN5O4

Calculated chemical properties:

MW 285.25
NB_atoms 20
XLogP -1.84
PSA 132.802
NB_HD 5
NB_HA 9
fsp3 0.50
Lipinski(0=no;1=yes) 1

FDA
-