e-Drug3D

1677

cas 123134-25-8

CLASS

NERVOUS SYSTEM
NARCOTICS
CENTRALLY ACTING OPIOID ANALGESIC
MU OPIOID RECEPTOR AGONIST

ROUTE (list)

ORAL

PK parameters

F 75 PERCENT
Tmax 2.3 HOUR
VD 188 LITER (65 KILOGRAM)
Cl 23 LITER / HOUR (65 KILOGRAM)
PPB 20 PERCENT
t1/2 6.7 HOUR

TARGET MU-TYPE OPIOID RECEPTOR

PDB
6M47 (X-RAY STRUCTURE OF A DROSOPHILA DOPAMINE TRANSPORTER WITH NET-LIKE MUTATIONS (D121G, S426M, F471L) IN TRAMADOL BOUND FORM)

Ligand code = F1U (link to the list of PDB complexes)

Download experimental 3D coordinates of F1U with added hydrogens

MW 263.37
NB_atoms 19
XLogP 2.63
PSA 33.429
NB_HD 1
NB_HA 3
fsp3 0.62
Lipinski(0=no;1=yes) 1

FDA
NDA 020281 (label) INN (TRAMADOL HYDROCHLORIDE) ULTRAM (JANSSEN PHARMS) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 021123 (label) INN (ACETAMINOPHEN ; TRAMADOL HYDROCHLORIDE) ULTRACET (JANSSEN PHARMS) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 075960 (label) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075962 (label) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075963 (pdf not found) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075964 (label) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (SUN PHARM INDS INC) APPROVAL= AP YEAR= 2002
NDA 075968 (label) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (GRAVITI PHARMS) APPROVAL= AP YEAR= 2002
NDA 075974 (label) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (ASTA) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075977 (label) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (TEVA) APPROVAL= AP YEAR= 2002
NDA 075980 (pdf not found) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (MYLAN PHARMS INC) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075981 (pdf not found) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (APOTEX) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075982 (pdf not found) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (PLIVA) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075983 (label) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (SPECGX LLC) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075986 (label) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (MYLAN) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 076003 (label) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (AMNEAL PHARMS) APPROVAL= AP YEAR= 2002
NDA 076100 (label) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 021692 (label) INN (TRAMADOL HYDROCHLORIDE) ULTRAM ER (VALEANT PHARMS) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 021693 (label) INN (TRAMADOL HYDROCHLORIDE) RYBIX ODT (SHIONOGI INC) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 076475 (pdf not found) INN (ACETAMINOPHEN ; TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (CHARTWELL RX) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 077184 (pdf not found) INN (ACETAMINOPHEN ; TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (SUN PHARM INDS INC) APPROVAL= AP YEAR= 2005
NDA 076914 (pdf not found) INN (ACETAMINOPHEN ; TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (GRAVITI PHARMS) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 077858 (pdf not found) INN (ACETAMINOPHEN ; TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (RISING) APPROVAL= AP YEAR= 2008
NDA 021745 (label) INN (TRAMADOL HYDROCHLORIDE) RYZOLT (PURDUE PHARMA) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078783 (pdf not found) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (STRIDES PHARMA) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 090485 (pdf not found) INN (ACETAMINOPHEN ; TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (AMNEAL PHARMS) APPROVAL= AP YEAR= 2009
NDA 022370 (label) INN (TRAMADOL HYDROCHLORIDE) CONZIP (CIPHER PHARMS INC) APPROVAL= AP YEAR= 2010
NDA 078935 (pdf not found) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (NORTHSTAR HLTHCARE) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 090404 (pdf not found) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (SENORES PHARMS) APPROVAL= AP YEAR= 2011
NDA 091607 (pdf not found) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (SUN PHARM) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 200503 (pdf not found) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (LUPIN LTD) APPROVAL= AP YEAR= 2011
NDA 201384 (pdf not found) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (SUN PHARM) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 202075 (pdf not found) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (STRIDES PHARMA) APPROVAL= AP YEAR= 2011
NDA 090460 (pdf not found) INN (ACETAMINOPHEN ; TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (ZYDUS PHARMS USA INC) APPROVAL= AP YEAR= 2012
NDA 091609 (pdf not found) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 200491 (pdf not found) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (PH HEALTH) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 201952 (pdf not found) INN (ACETAMINOPHEN ; TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (MICRO LABS LTD INDIA) APPROVAL= AP YEAR= 2012
NDA 201973 (pdf not found) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (IPCA LABS LTD) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 202076 (pdf not found) INN (ACETAMINOPHEN ; TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (ALKEM LABS LTD) APPROVAL= AP YEAR= 2012
NDA 091498 (pdf not found) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (CSPC OUYI PHARM CO) APPROVAL= AP YEAR= 2013
NDA 202390 (pdf not found) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 078778 (pdf not found) INN (ACETAMINOPHEN ; TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (NOSTRUM LABS INC) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 203494 (pdf not found) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2014
NDA 205702 (pdf not found) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 204421 (label) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 205257 (pdf not found) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (MYLAN) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 206885 (pdf not found) INN (ACETAMINOPHEN ; TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 207152 (pdf not found) INN (ACETAMINOPHEN ; TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE AND ACETAMINOPHEN (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2017
NDA 206706 (pdf not found) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (MERRO PHARM USA) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 208708 (pdf not found) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (RUBICON RESEARCH) APPROVAL= AP YEAR= 2019
NDA 211825 (pdf not found) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (UNICHEM) APPROVAL= AP YEAR= 2019
NDA 214044 (label) INN (TRAMADOL HYDROCHLORIDE) QDOLO (ATHENA) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 213426 (label) INN (CELECOXIB ; TRAMADOL HYDROCHLORIDE) SEGLENTIS (KOWA PHARMS) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 209404 (pdf not found) INN (TRAMADOL HYDROCHLORIDE) TRAMADOL HYDROCHLORIDE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2025