e-Drug3D

1665

M LATANOPROST

INN
LATANOPROST

cas 41639-83-2

CLASS

SENSORY
ANTIGLAUCOMA
ANTIHYPERTENSIVE AGENTS
PROSTANOID

ROUTE (list)

PK parameters

VD 10.4 LITER (65 KILOGRAM)
Cl 27.3 LITER / HOUR (65 KILOGRAM)
t1/2 0.28 HOUR

Target

TARGET PROSTAGLANDIN F2-ALPHA RECEPTOR

PDB
8XJM (LATANOPROST ACID BOUND PROSTAGLANDIN F2-ALPHA RECEPTOR-GQ PROTEIN COMPLEX)

Download experimental 3D coordinates of 7WT with added hydrogens

Prostaglandin F2-alpha receptor UNIPROT P43088 PTGFR

Download SDF file

5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-, (5Z)-

Formula:
C23H34O5

Calculated chemical properties:

MW 389.49
NB_atoms 28
XLogP 1.98
PSA 94.359
NB_HD 3
NB_HA 5
fsp3 0.61
Lipinski(0=no;1=yes) 1

FDA
-