e-Drug3D

1644

ADEFOVIR

INN
ADEFOVIR

cas 106941-25-7

CLASS

ANTIINFECTIVES
ANTIVIRAL AGENTS
REVERSE TRANSCRIPTASE INHIBITORS
TREATMENT OF CHRONIC HEPATITIS B

ROUTE (list)

ATC code

J05AF08

PK parameters

F 59 PERCENT
Tmax 1.75 HOUR
VD 25.4 LITER (65 KILOGRAM)
Cl 14.4 LITER / HOUR (65 KILOGRAM)
PPB 4 PERCENT
t1/2 7.48 HOUR

Target

TARGET HBV REVERSE TRANSCRIPTASE

PDB
2G1A (CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN APHA CLASS B ACID PHOSPHATASE, PHOSPHOTRANSFERASE)

Download experimental 3D coordinates of 5HG with added hydrogens

Protein P UNIPROT Q9IF40 P

Download SDF file

2-(6-amino-9h-purin-9-yl)ethoxy]methylphosphonic acid

Formula:
C8H12N5O4P

Calculated chemical properties:

MW 271.18
NB_atoms 18
XLogP -1.70
PSA 125.277
NB_HD 2
NB_HA 9
fsp3 0.38
Lipinski(0=no;1=yes) 1

FDA
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