e-Drug3D

1641

M CLOFARABINE

INN
CLOFARABINE

cas 134646-41-6

CLASS

ANTINEOPLASTIC
ANTIMETABOLITES
PURINE ANALOGUES
INHIBITS DNA SYNTHESIS

ROUTE (list)

ATC code

L01BB06

PK parameters

Target

TARGET RIBONUCLEOTIDE REDUCTASE

DNA polymerase alpha catalytic subunit UNIPROT P09884 POLA1

Ribonucleoside-diphosphate reductase large subunit UNIPROT P23921 RRM1

Download SDF file

9H-Purin-6-amine, 2-chloro-9-[2-deoxy-2-fluoro-5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-beta-D-arabinofuranosyl]-

Formula:
C10H14ClFN5O12P3

Calculated chemical properties:

MW 539.59
NB_atoms 32
XLogP -2.53
PSA 243.818
NB_HD 3
NB_HA 17
fsp3 0.50
Lipinski(0=no;1=yes) 0

FDA
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