e-Drug3D

1637

M TETRABENAZINE

INN
TETRABENAZINE

cas 85081-18-1

CLASS

NERVOUS SYSTEM
CNS
TREATMENT OF CHOREA ASSOCIATED WITH HUNTINGTON DISEASE
INHIBITOR
IS BELIEVED TO BE RELATED TO ITS EFFECT AS A REVERSIBLE DEPLETOR OF MONOAMINES (SUCH AS DOPAMINE, SEROTONIN, NOREPINEPHRINE, AND HISTAMINE) FROM NERVE TERMINALS
VESICULAR MONOAMINE TRANSPORTER TYPE 2 (VMAT2) (KI=100 NANOMOLAR)

ROUTE (list)

ATC code

N07XX06

PK parameters

Tmax 1 HOUR
PPB 64 PERCENT
t1/2 7 HOUR

Target

TARGET VESICULAR MONOAMINE TRANSPORTER TYPE 2 (VMAT2)

DrugCentral

Synaptic vesicular amine transporter UNIPROT Q05940 SLC18A2

Download SDF file

2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (2R,3R,11bR)-

Formula:
C19H29NO3

Calculated chemical properties:

MW 319.43
NB_atoms 23
XLogP 3.03
PSA 46.261
NB_HD 1
NB_HA 4
fsp3 0.68
Lipinski(0=no;1=yes) 1

FDA
-