e-Drug3D

1631

LULICONAZOLE

INN
LULICONAZOLE

cas 187164-19-8

CLASS

ANTIINFECTIVES
AZOLE ANTIFUNGAL
TOPICAL TREATMENT OF INTERDIGITAL TINEA PEDIS, TINEA CRURIS, AND TINEA CORPORIS CAUSED BY THE ORGANISMS TRICHOPHYTON RUBRUM AND EPIDERMOPHYTON FLOCCOSUM
APPEARS TO INHIBIT ERGOSTEROL SYNTHESIS (CONSTITUENT OF FUNGAL CELL MEMBRANES) BY INHIBITING THE ENZYME LANOSTEROL DEMETHYLASE

ROUTE (list)

TOPICAL

ATC code

D01AC18

PK parameters

PPB 99 PERCENT

Target

TARGET LANOSTEROL DEMETHYLASE

DrugCentral

Lanosterol 14-alpha demethylase UNIPROT P10613 ERG11

Download SDF file

(2E)-2-[(4R)-4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-2-imidazol-1-ylacetonitrile

Formula:
C14H9Cl2N3S2

Calculated chemical properties:

MW 354.28
NB_atoms 21
XLogP 5.06
PSA 31.943
NB_HD 0
NB_HA 3
fsp3 0.14
Lipinski(0=no;1=yes) 0

FDA
NDA 204153 (label) INN (LULICONAZOLE) LUZU (BAUSCH) APPROVAL= AP YEAR= 2013 NEWMOLECULARENTITY