e-Drug3D
1629
UMECLIDINIUM
INN
UMECLIDINIUM
cas 869113-09-7
CLASS
RESPIRATORY
ANTICHOLINERGIC
ANTIMUSCARINIC AGENT
MUSCARINIC RECEPTORS ANTAGONISTS
INDICATED FOR THE LONG-TERM, ONCE-DAILY, MAINTENANCE TREATMENT OF AIRFLOW OBSTRUCTION IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)
ROUTE (list)
INHALATION
ATC code
R03AL03
PK parameters
VD 86 LITER
Cl 5.4 LITER / HOUR (EQN)
PPB 89 PERCENT
t1/2 11 HOUR
Solubility
SLIGHTLY SOLUBLE IN WATER
TARGET MUSCARINIC RECEPTORS M1 TO M5
Muscarinic acetylcholine receptor M3 UNIPROT P20309 CHRM3
Formula:
C29H34NO2
Calculated chemical properties:
MW 428.57
NB_atoms 32
XLogP 5.14
PSA 23.41
NB_HD 1
NB_HA 2
fsp3 0.38
Lipinski(0=no;1=yes) 0
NB_atoms 32
XLogP 5.14
PSA 23.41
NB_HD 1
NB_HA 2
fsp3 0.38
Lipinski(0=no;1=yes) 0
FDA
NDA 203975 (pdf not found) INN (UMECLIDINIUM BROMIDE ; VILANTEROL TRIFENATATE) ANORO ELLIPTA (GLAXOSMITHKLINE) APPROVAL= AP YEAR= 2013
NDA 205382 (pdf not found) INN (UMECLIDINIUM BROMIDE) INCRUSE ELLIPTA (GLAXO GRP ENGLAND) APPROVAL= AP YEAR= 2014
NDA 209482 (pdf not found) INN (FLUTICASONE FUROATE ; UMECLIDINIUM BROMIDE ; VILANTEROL TRIFENATATE) TRELEGY ELLIPTA (GLAXOSMITHKLINE) APPROVAL= AP YEAR= 2017
NDA 203975 (pdf not found) INN (UMECLIDINIUM BROMIDE ; VILANTEROL TRIFENATATE) ANORO ELLIPTA (GLAXOSMITHKLINE) APPROVAL= AP YEAR= 2013
NDA 205382 (pdf not found) INN (UMECLIDINIUM BROMIDE) INCRUSE ELLIPTA (GLAXO GRP ENGLAND) APPROVAL= AP YEAR= 2014
NDA 209482 (pdf not found) INN (FLUTICASONE FUROATE ; UMECLIDINIUM BROMIDE ; VILANTEROL TRIFENATATE) TRELEGY ELLIPTA (GLAXOSMITHKLINE) APPROVAL= AP YEAR= 2017