e-Drug3D

162

cas 118-42-3

CLASS

ANTIPARASITIC
ANTIMALARIAL
LUPUS SUPPRESSANT
ANTIRHEUMATIC AGENTS
AUTOPHAGY INHIBITOR

ROUTE (list)

ORAL

PK parameters

Tmax 2.4 HOUR
VD 2851 LITER
Cl 12 LITER / HOUR
PPB 43 PERCENT
t1/2 172.3 HOUR

-

PDB
8S5Z (CRYO-EM STRUCTURE OF HYDROXYCHLOROQUINE-BOUND HUMAN SLC19A3 IN INWARD-OPEN STATE )

Ligand code = A1H5D (link to the list of PDB complexes)

Download experimental 3D coordinates of A1H5D with added hydrogens

MW 335.87
NB_atoms 23
XLogP 3.78
PSA 44.66
NB_HD 2
NB_HA 4
fsp3 0.50
Lipinski(0=no;1=yes) 1

FDA
NDA 009768 (label) INN (HYDROXYCHLOROQUINE SULFATE) PLAQUENIL (ADVANZ PHARMA) APPROVAL= AP YEAR= 1955
NDA 040081 (pdf not found) INN (HYDROXYCHLOROQUINE SULFATE) HYDROXYCHLOROQUINE SULFATE (TEVA PHARMS) APPROVAL= AP YEAR= 1994
NDA 040104 (label) INN (HYDROXYCHLOROQUINE SULFATE) HYDROXYCHLOROQUINE SULFATE (SANDOZ) APPROVAL= AP YEAR= 1995
NDA 040133 (pdf not found) INN (HYDROXYCHLOROQUINE SULFATE) HYDROXYCHLOROQUINE SULFATE (WATSON LABS) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 040150 (label) INN (HYDROXYCHLOROQUINE SULFATE) HYDROXYCHLOROQUINE SULFATE (CREEKWOOD PHARMS) APPROVAL= AP YEAR= 1996
NDA 040274 (label) INN (HYDROXYCHLOROQUINE SULFATE) HYDROXYCHLOROQUINE SULFATE (AUROBINDO PHARMA USA) APPROVAL= AP YEAR= 1998
NDA 040657 (label) INN (HYDROXYCHLOROQUINE SULFATE) HYDROXYCHLOROQUINE SULFATE (ZYDUS PHARMS USA INC) APPROVAL= AP YEAR= 2007
NDA 040760 (label) INN (HYDROXYCHLOROQUINE SULFATE) HYDROXYCHLOROQUINE SULFATE (HIKMA PHARMS) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 040766 (label) INN (HYDROXYCHLOROQUINE SULFATE) HYDROXYCHLOROQUINE SULFATE (IPCA LABS LTD) APPROVAL= AP YEAR= 2007
NDA 201691 (label) INN (HYDROXYCHLOROQUINE SULFATE) HYDROXYCHLOROQUINE SULFATE (ALKALOIDA ZRT) APPROVAL= AP YEAR= 2018
NDA 210441 (label) INN (HYDROXYCHLOROQUINE SULFATE) HYDROXYCHLOROQUINE SULFATE (APPCO) APPROVAL= AP YEAR= 2018
NDA 210577 (pdf not found) INN (HYDROXYCHLOROQUINE SULFATE) HYDROXYCHLOROQUINE SULFATE (AMNEAL PHARMS CO) APPROVAL= AP YEAR= 2018
NDA 210543 (label) INN (HYDROXYCHLOROQUINE SULFATE) HYDROXYCHLOROQUINE SULFATE (CHARTWELL RX) APPROVAL= AP YEAR= 2018
NDA 210959 (label) INN (HYDROXYCHLOROQUINE SULFATE) HYDROXYCHLOROQUINE SULFATE (LAURUS) APPROVAL= AP YEAR= 2019
NDA 212902 (pdf not found) INN (HYDROXYCHLOROQUINE SULFATE) HYDROXYCHLOROQUINE SULFATE (SENORES PHARMS) APPROVAL= AP YEAR= 2020
NDA 213342 (pdf not found) INN (HYDROXYCHLOROQUINE SULFATE) HYDROXYCHLOROQUINE SULFATE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2020
NDA 214581 (label) INN (HYDROXYCHLOROQUINE SULFATE) SOVUNA (NOVITIUM PHARMA) APPROVAL= AP YEAR= 2022