e-Drug3D

1619

cas 96847-54-0

CLASS

NERVOUS SYSTEM
TREATMENT OF MAJOR DEPRESSIVE DISORDER
SEROTONIN (KI=11 NANOMOLAR) AND NOREPINEPHRINE (KI=91 NANOMOLAR) REUPTAKE INHIBITOR

ROUTE (list)

ORAL

PK parameters

F 92 PERCENT
VD 430 LITER
Cl 25 LITER / HOUR
PPB 22 PERCENT
t1/2 12 HOUR

MW 246.35
NB_atoms 18
XLogP 1.77
PSA 43.268
NB_HD 2
NB_HA 3
fsp3 0.53
Lipinski(0=no;1=yes) 1

FDA
NDA 204168 (label) INN (LEVOMILNACIPRAN HYDROCHLORIDE) FETZIMA (ABBVIE) APPROVAL= AP YEAR= 2013
NDA 210790 (pdf not found) INN (LEVOMILNACIPRAN HYDROCHLORIDE) LEVOMILNACIPRAN HYDROCHLORIDE (AMNEAL PHARMS CO) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 210805 (pdf not found) INN (LEVOMILNACIPRAN) LEVOMILNACIPRAN (MSN LABORATORIES PRIVATE LTD) APPROVAL= TA YEAR= 2020
NDA 210732 (pdf not found) INN (LEVOMILNACIPRAN HYDROCHLORIDE) LEVOMILNACIPRAN HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 210771 (pdf not found) INN (LEVOMILNACIPRAN HYDROCHLORIDE) LEVOMILNACIPRAN HYDROCHLORIDE (PRINSTON INC) APPROVAL= AP YEAR= 2023
NDA 210826 (pdf not found) INN (LEVOMILNACIPRAN HYDROCHLORIDE) LEVOMILNACIPRAN HYDROCHLORIDE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 210857 (pdf not found) INN (LEVOMILNACIPRAN) LEVOMILNACIPRAN (ZYDUS PHARMS USA INC) APPROVAL= TA YEAR= 2023