1607

INN
PHENYLACETATE

(is an active metabolite)

NITROGEN-BINDING AGENT FOR CHRONIC UREAC CYCLE DISORDERS (UCDS)
AMMONIA SCAVENGER
SUBSTRATE METABOLIZED BY PHENYLACETYL-COA: L-GLUTAMINE-N-ACETYLTRANSFERASE
COMPOUND THAT CONJUGATES WITH GLUTAMINE VIA ACETYLATION TO FORM PHENYLACETYLGLUTAMINE
PHENYLACETYLGLUTAMINE THEN IS EXCRETED BY THE KIDNEYS
ON A MOLAR BASIS, IT IS COMPARABLE TO UREA (EACH CONTAINING TWO MOLES OF NITROGEN)
THEREFORE, PHENYLACETYLGLUTAMINE PROVIDES AN ALTERNATE VEHICLE FOR WASTE NITROGEN EXCRETION

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Tmax 3.7 HOUR
PPB 51 PERCENT
t1/2 1.15 HOUR

SOLUBLE IN WATER

PDB
2ISF (CRYSTAL STRUCTURE OF C298A W219Y ALDOSE REDUCTASE COMPLEXED WITH PHENYLACETIC ACID)

Ligand code = PAC (link to the list of PDB complexes)

Download experimental 3D coordinates of PAC with added hydrogens