e-Drug3D
1604
cas 611168-24-2
CLASS
NITROGEN-BINDING AGENT FOR CHRONIC UREAC CYCLE DISORDERS (UCDS)
AMMONIA SCAVENGER
SUBSTRATE METABOLIZED BY LIPASES (PANCREATIC TRIGLYCERIDE LIPASE, CARBOXYL ESTER LIPASE, AND PANCREATIC LIPASE–RELATED PROTEIN 2) AND BY ESTERASES IN HUMAN PLASMA (IN VITRO)
ROUTE (list)
ORAL
ATC code
A16AX09
PK parameters
Solubility
INSOLUBLE IN WATER
TARGET PANCREATIC TRIGLYCERIDE LIPASE
CARBOXYL ESTER LIPASE
PANCREATIC LIPASE RELATED PROTEIN 2
HUMAN ESTERASES
Unknown
Formula:
C33H38O6
Calculated chemical properties:
MW 530.63
NB_atoms 39
XLogP 6.05
PSA 74.669
NB_HD 0
NB_HA 6
fsp3 0.36
Lipinski(0=no;1=yes) 0
NB_atoms 39
XLogP 6.05
PSA 74.669
NB_HD 0
NB_HA 6
fsp3 0.36
Lipinski(0=no;1=yes) 0
FDA
NDA 203284 (label) INN (GLYCEROL PHENYLBUTYRATE) RAVICTI (HORIZON THERAP US) APPROVAL= AP YEAR= 2013
NDA 205742 (pdf not found) INN (GLYCEROL PHENYLBUTYRATE) GLYCEROL PHENYLBUTYRATE (PH HEALTH) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 215139 (pdf not found) INN (GLYCEROL PHENYLBUTYRATE) GLYCEROL PHENYLBUTYRATE (ANNORA PHARMA) APPROVAL= TA YEAR= 2022
NDA 203284 (label) INN (GLYCEROL PHENYLBUTYRATE) RAVICTI (HORIZON THERAP US) APPROVAL= AP YEAR= 2013
NDA 205742 (pdf not found) INN (GLYCEROL PHENYLBUTYRATE) GLYCEROL PHENYLBUTYRATE (PH HEALTH) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 215139 (pdf not found) INN (GLYCEROL PHENYLBUTYRATE) GLYCEROL PHENYLBUTYRATE (ANNORA PHARMA) APPROVAL= TA YEAR= 2022