e-Drug3D

1600

TRAMETINIB

INN
TRAMETINIB

cas 871700-17-3

CLASS

ANTINEOPLASTIC
KINASE INHIBITOR
METASTATIC MELANOMA WITH BRAF V600E OR V600K MUTATIONS

ROUTE (list)

ORAL

ATC code

L01EE01

PK parameters

F 72 PERCENT
VD 214 LITER
Cl 4.9 LITER / HOUR
PPB 97.4 PERCENT
t1/2 4.35 HOUR

Solubility

PRACTICALLY INSOLUBLE IN THE PH RANGE OF 2 TO 8 IN WATER

Target

TARGET MEK1
MEK2

PDB
7JUR (CRYSTAL STRUCTURE OF KSR2:MEK1 IN COMPLEX WITH AMP-PNP AND ALLOSTERIC MEK INHIBITOR TRAMETINIB)

Ligand code = QOM (link to the list of PDB complexes)

Download experimental 3D coordinates of QOM with added hydrogens

DrugCentral

Dual specificity mitogen-activated protein kinase kinase 1 UNIPROT Q02750 MAP2K1

Dual specificity mitogen-activated protein kinase kinase 2 UNIPROT P36507 MAP2K2

Download SDF file

Acetamide, N-[3-[3-cyclopropyl-5-[(2-fluoro-4-iodophenyl)amino]-3,4,6,7-tetrahydro-6,8-dimethyl-2,4,7-trioxopyrido[4,3-d]pyrimidin-1(2H)-yl]phenyl]-

Formula:
C26H23FIN5O4

Calculated chemical properties:

MW 615.39
NB_atoms 37
XLogP 3.94
PSA 90.284
NB_HD 2
NB_HA 9
fsp3 0.23
Lipinski(0=no;1=yes) 0

FDA
NDA 204114 (pdf not found) INN (TRAMETINIB DIMETHYL SULFOXIDE) MEKINIST (NOVARTIS) APPROVAL= AP YEAR= 2013
NDA 217513 (pdf not found) INN (TRAMETINIB DIMETHYL SULFOXIDE) MEKINIST (NOVARTIS) APPROVAL= AP YEAR= 2023
NDA 219002 (pdf not found) INN (TRAMETINIB DIMETHYL SULFOXIDE) TRAMETINIB DIMETHYL SULFOXIDE (HIKMA) APPROVAL= AP YEAR= 2024 DISCONTINUED