e-Drug3D

1599

POMALIDOMIDE

INN
POMALIDOMIDE

cas 19171-19-8

CLASS

ANTINEOPLASTIC
THALIDOMIDE ANALOG
TREATMENT OF MULTIPLE MYELOMA
IMMUNOMODULATORY AGENT

ROUTE (list)

ORAL

ATC code

L04AX06

PK parameters

VD 100 LITER
Cl 8 LITER / HOUR
PPB 28 PERCENT
t1/2 9.5 HOUR

Solubility

LOW SOLUBILITY IN WATER

Target

PDB
7SZA (CRYSTAL STRUCTURE ANALYSIS OF HUMAN PRPK COMPLEX WITH A COMPOUND)

Ligand code = DUI (link to the list of PDB complexes)

Download experimental 3D coordinates of DUI with added hydrogens

DrugCentral

Protein cereblon UNIPROT Q96SW2 CRBN

Download SDF file

1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-

Formula:
C13H11N3O4

Calculated chemical properties:

MW 273.25
NB_atoms 20
XLogP -0.33
PSA 102.718
NB_HD 3
NB_HA 7
fsp3 0.23
Lipinski(0=no;1=yes) 1

FDA
NDA 204026 (pdf not found) INN (POMALIDOMIDE) POMALYST (BRISTOL) APPROVAL= AP YEAR= 2013
NDA 210111 (pdf not found) INN (POMALIDOMIDE) POMALIDOMIDE (BRECKENRIDGE) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 210249 (pdf not found) INN (POMALIDOMIDE) POMALIDOMIDE (EUGIA PHARMA) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 209956 (pdf not found) INN (POMALIDOMIDE) POMALIDOMIDE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 210275 (pdf not found) INN (POMALIDOMIDE) POMALIDOMIDE (MYLAN) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 213234 (pdf not found) INN (POMALIDOMIDE) POMALIDOMIDE (DR REDDYS LABS LTD) APPROVAL= TA YEAR= 2024
NDA 210164 (pdf not found) INN (POMALIDOMIDE) POMALIDOMIDE (APOTEX) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 210236 (pdf not found) INN (POMALIDOMIDE) POMALIDOMIDE (HETERO LABS LTD V) APPROVAL= AP YEAR= 2024 DISCONTINUED