e-Drug3D

1583

MIRABEGRON

INN
MIRABEGRON

cas 223673-61-8

CLASS

GENITO
TREATMENT OF OVERACTIVE BLADDER (OAB)
AGONIST OF BETA-3 ADRENERGIC RECEPTOR (AR)

ROUTE (list)

ORAL

ATC code

G04BD12

PK parameters

F 29 PERCENT
VD 1670 LITER
Cl 57 LITER / HOUR
PPB 71 PERCENT
t1/2 50 HOUR

Solubility

PRACTICALLY INSOLUBLE IN WATER 0.082 MILLIGRAM / MILLILITER

Target

TARGET BETA-3 ADRENERGIC RECEPTOR

PDB
7DH5 (DOG BETA3 ADRENERGIC RECEPTOR BOUND TO MIRABEGRON IN COMPLEX WITH A MINIGS HETEROTRIMER)

Ligand code = H6U (link to the list of PDB complexes)

Download experimental 3D coordinates of H6U with added hydrogens

DrugCentral

Beta-3 adrenergic receptor UNIPROT P13945 ADRB3

Download SDF file

4-Thiazoleacetamide, 2-amino-N-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]-

Formula:
C21H24N4O2S

Calculated chemical properties:

MW 396.51
NB_atoms 28
XLogP 2.77
PSA 93.357
NB_HD 5
NB_HA 6
fsp3 0.24
Lipinski(0=no;1=yes) 1

FDA
NDA 202611 (pdf not found) INN (MIRABEGRON) MYRBETRIQ (APGDI) APPROVAL= AP YEAR= 2012 NEWMOLECULARENTITY
NDA 209413 (pdf not found) INN (MIRABEGRON) MIRABEGRON (AUROBINDO PHARMA LTD) APPROVAL= TA YEAR= 2018
NDA 209446 (pdf not found) INN (MIRABEGRON) MIRABEGRON (SAWAI USA) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 213801 (pdf not found) INN (MIRABEGRON) MYRBETRIQ GRANULES (APGDI) APPROVAL= AP YEAR= 2021
NDA 209485 (pdf not found) INN (MIRABEGRON) MIRABEGRON (LUPIN LTD) APPROVAL= AP YEAR= 2022
NDA 209488 (pdf not found) INN (MIRABEGRON) MIRABEGRON (ZYDUS PHARMS) APPROVAL= AP YEAR= 2022
NDA 215948 (pdf not found) INN (MIRABEGRON) MIRABEGRON (ALKEM LABS LTD) APPROVAL= AP YEAR= 2024
NDA 209434 (pdf not found) INN (MIRABEGRON) MIRABEGRON (APOTEX) APPROVAL= AP YEAR= 2025 DISCONTINUED
NDA 217061 (pdf not found) INN (MIRABEGRON) MIRABEGRON (SAWAI USA) APPROVAL= AP YEAR= 2025 DISCONTINUED
NDA 217989 (pdf not found) INN (MIRABEGRON) MIRABEGRON (QILU) APPROVAL= AP YEAR= 2025
NDA 218172 (pdf not found) INN (MIRABEGRON) MIRABEGRON (ASCENT PHARMS INC) APPROVAL= TA YEAR= 2025