e-Drug3D

1580

CARFILZOMIB

INN
CARFILZOMIB

cas 868540-17-4

CLASS

ANTINEOPLATIC
TREATMENT OF MULTIPLE MYELOMA
PROTEASOME INHIBITOR THAT IRREVERSIBLY (COVALENTLY) BINDS TO THE N-TERMINAL THREONINE-CONTAINING ACTIVE SITES OF THE 20S PROTEASOME

ROUTE (list)

INTRAVENOUS INJECTION

ATC code

L01XG02

PK parameters

VD 28 LITER
Cl 207 LITER / HOUR
PPB 97 PERCENT
t1/2 1 HOUR

Solubility

PRACTICALLY INSOLUBLE IN WATER

Target

TARGET 20S PROTEASOME

DrugCentral

Proteasome subunit beta type-5 UNIPROT P28074 PSMB5

Download SDF file

(2S)-N-((S)-1-((S)-4-methyl-1-((R)-2-methyloxiran2-yl)-1-oxopentan-2-ylcarbamoyl)-2-phenylethyl)-2-((S)-2-(2-morpholinoacetamido)4-phenylbutanamido)-4-methylpentanamide

Formula:
C40H57N5O7

Calculated chemical properties:

MW 719.91
NB_atoms 52
XLogP 2.58
PSA 150.199
NB_HD 4
NB_HA 12
fsp3 0.57
Lipinski(0=no;1=yes) 0

FDA
NDA 202714 (pdf not found) INN (CARFILZOMIB) KYPROLIS (ONYX PHARMS AMGEN) APPROVAL= AP YEAR= 2012
NDA 209528 (pdf not found) INN (CARFILZOMIB) CARFILZOMIB (QILU PHARM CO LTD) APPROVAL= TA YEAR= 2019
NDA 209422 (pdf not found) INN (CARFILZOMIB) CARFILZOMIB (DR REDDYS) APPROVAL= AP YEAR= 2019
NDA 209425 (pdf not found) INN (CARFILZOMIB) CARFILZOMIB (APOTEX) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 211185 (pdf not found) INN (CARFILZOMIB) CARFILZOMIB (APOTEX) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 209330 (pdf not found) INN (CARFILZOMIB) CARFILZOMIB (BRECKENRIDGE) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 210823 (pdf not found) INN (CARFILZOMIB) CARFILZOMIB (EUGIA PHARMA) APPROVAL= TA YEAR= 2022
NDA 209526 (pdf not found) INN (CARFILZOMIB) CARFILZOMIB (MSN PHARMACEUTICALS INC) APPROVAL= TA YEAR= 2023