e-Drug3D

1573

cas 86227-47-6

CLASS

CARDIOVASCULAR
ADJUNCT TO DIET TO REDUCE TRIGLYCERIDE (TG) LEVELS IN ADULT PATIENTS WITH SEVERE (>= 500 MG/DL) HYPERTRIGLYCERIDEMIA
POTENTIAL MECHANISMS OF ACTION INCLUDE INCREASED BETA-OXIDATION
INHIBITION OF ACYL-COA:1,2-DIACYLGLYCEROL ACYLTRANSFERASE (DGAT)
DECREASED LIPOGENESIS IN THE LIVER
AND INCREASED PLASMA LIPOPROTEIN LIPASE ACTIVITY

ROUTE (list)

ORAL

PK parameters

MW 330.49
NB_atoms 24
XLogP 6.47
PSA 26.066
NB_HD 0
NB_HA 2
fsp3 0.50
Lipinski(0=no;1=yes) 0

FDA
NDA 202057 (pdf not found) INN (ICOSAPENT ETHYL) VASCEPA (AMARIN PHARMS) APPROVAL= AP YEAR= 2012
NDA 209457 (pdf not found) INN (ICOSAPENT ETHYL) ICOSAPENT ETHYL (HIKMA) APPROVAL= AP YEAR= 2020
NDA 209499 (pdf not found) INN (ICOSAPENT ETHYL) ICOSAPENT ETHYL (DR REDDYS) APPROVAL= AP YEAR= 2020
NDA 209525 (pdf not found) INN (ICOSAPENT ETHYL) ICOSAPENT ETHYL (TEVA PHARMS USA) APPROVAL= AP YEAR= 2020
NDA 209437 (pdf not found) INN (ICOSAPENT ETHYL) ICOSAPENT ETHYL (APOTEX) APPROVAL= AP YEAR= 2021
NDA 217656 (pdf not found) INN (ICOSAPENT ETHYL) ICOSAPENT ETHYL (ZYDUS LIFESCIENCES) APPROVAL= AP YEAR= 2023
NDA 216811 (pdf not found) INN (ICOSAPENT ETHYL) ICOSAPENT ETHYL (ASCENT PHARMS INC) APPROVAL= AP YEAR= 2023
NDA 217844 (pdf not found) INN (ICOSAPENT ETHYL) ICOSAPENT ETHYL (ONESOURCE SPECIALTY) APPROVAL= AP YEAR= 2023
NDA 217919 (pdf not found) INN (ICOSAPENT ETHYL) ICOSAPENT ETHYL (HUMANWELL PURACAP) APPROVAL= AP YEAR= 2023
NDA 218899 (pdf not found) INN (ICOSAPENT ETHYL) ICOSAPENT ETHYL (QILU) APPROVAL= AP YEAR= 2024
NDA 218994 (pdf not found) INN (ICOSAPENT ETHYL) ICOSAPENT ETHYL (SPRIASO LLC) APPROVAL= AP YEAR= 2024
NDA 219156 (pdf not found) INN (ICOSAPENT ETHYL) ICOSAPENT ETHYL (XIAMEN LP PHARM CO) APPROVAL= AP YEAR= 2025