e-Drug3D

1572

LOMITAPIDE

INN
LOMITAPIDE

cas 182431-12-5

CLASS

CARDIOVASCULAR
INHIBITOR OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) AND REDUCED LEVELS OF PLASMA LDL-C

ROUTE (list)

ORAL

ATC code

C10AX12

PK parameters

F 7 PERCENT
VD 1138 LITER
Cl 19.8 LITER / HOUR (EQN)
PPB 99.8 PERCENT
t1/2 39.7 HOUR

Solubility

SLIGHTLY SOLUBLE IN AQUEOUS SOLUTIONS OF PH 2 TO 5

Target

TARGET MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN

Microsomal triglyceride transfer protein large subunit UNIPROT P55157 MTTP

Download SDF file

N-(2,2,2-trifluoroethyl)-9-[4-[4-[[[4'(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1-piperidinyl]butyl]-9H-fluorene-9carboxamide

Formula:
C39H37F6N3O2

Calculated chemical properties:

MW 693.72
NB_atoms 50
XLogP 8.38
PSA 58.631
NB_HD 2
NB_HA 5
fsp3 0.33
Lipinski(0=no;1=yes) 0

FDA
NDA 203858 (pdf not found) INN (LOMITAPIDE MESYLATE) JUXTAPID (CHIESI) APPROVAL= AP YEAR= 2012 NEWMOLECULARENTITY