1567
NERVOUS SYSTEM
ANTIPSYCHOTIC
SCHIZOPHRENIA
DIBENZOTHIAZEPINE FAMILY
DOPAMINE D2 RECEPTOR ANTAGONIST (IC50=329 NANOMOLAR)
SEROTONIN (5HT2) ANTAGONIST (IC50=148 NANOMOLAR)
SEROTONIN 5HT1A ANTAGONIST (IC50=717 NANOMOLAR)
DOPAMINE D1 ANTAGONIST (IC50=1268 NANOMOLAR)
HISTAMINE H1 ANTAGONIST (IC50=30 NANOMOLAR)
ADRENERGIC ALPHA 1 RECEPTOR ANTAGONIST (IC50= 94 NANOMOLAR)
ADRENARGIC ALPHA 2 RECEPTOR ANTAGONIST (IC50=271 NANOMOLAR)
NO APPRECIABLE AFFINITY AT CHOLINERGIC MUSCARINIC AND BENZODIAZEPINE RECEPTORS (IC50 SUPERIOR TO 5000 NANOMOLAR)
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ATC code
N05AH04
TARGET 5-HYDROXYTRYPTAMINE 2 RECEPTOR
D2 DOPAMINE RECEPTOR
D(2) dopamine receptor UNIPROT P14416 DRD2
5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A
Formula:
C17H17N3S
Calculated chemical properties:
NB_atoms 21
XLogP 3.13
PSA 25.567
NB_HD 1
NB_HA 3
fsp3 0.24
Lipinski(0=no;1=yes) 1
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