e-Drug3D

155

cas 55-98-1

CLASS

ANTINEOPLASTIC
ALKYLATING AGENTS
IMMUNOSUPPRESSIVE AGENTS
MYELOABLATIVE AGONISTS
PRODUCES REACTIVE CARBONIUM IONS THAT CAN ALKYLATE DNA

ROUTE (list)

ORAL INJECTION

PK parameters

VD 41.6 LITER (65 KILOGRAM)
Cl 9.8 LITER / HOUR (65 KILOGRAM)
PPB 32.4 PERCENT
t1/2 3.4 HOUR

MW 246.31
NB_atoms 14
XLogP -0.28
PSA 88.143
NB_HD 0
NB_HA 6
fsp3 1.00
Lipinski(0=no;1=yes) 1

FDA
NDA 009386 (label) INN (BUSULFAN) MYLERAN (WAYLIS THERAP) APPROVAL= AP YEAR= 1954
NDA 020954 (label) INN (BUSULFAN) BUSULFEX (OTSUKA PHARM) APPROVAL= AP YEAR= 1999
NDA 202259 (pdf not found) INN (BUSULFAN) BUSULFAN (AM REGENT) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 207050 (pdf not found) INN (BUSULFAN) BUSULFAN (PHARMASCIENCE INC) APPROVAL= AP YEAR= 2017
NDA 205139 (pdf not found) INN (BUSULFAN) BUSULFAN (ACTAVIS) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 208536 (pdf not found) INN (BUSULFAN) BUSULFAN (MYLAN INSTITUTIONAL) APPROVAL= AP YEAR= 2017
NDA 209580 (pdf not found) INN (BUSULFAN) BUSULFAN (AMNEAL) APPROVAL= AP YEAR= 2017
NDA 205106 (pdf not found) INN (BUSULFAN) BUSULFAN (ARTHUR GRP) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 205184 (pdf not found) INN (BUSULFAN) BUSULFAN (PHARMOBEDIENT) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 205672 (pdf not found) INN (BUSULFAN) BUSULFAN (HOSPIRA) APPROVAL= AP YEAR= 2018
NDA 207794 (pdf not found) INN (BUSULFAN) BUSULFAN (NEXUS) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 210148 (pdf not found) INN (BUSULFAN) BUSULFAN (ACCORD HLTHCARE INC) APPROVAL= AP YEAR= 2019
NDA 210448 (pdf not found) INN (BUSULFAN) BUSULFAN (APOTEX) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 210931 (pdf not found) INN (BUSULFAN) BUSULFAN (SHILPA) APPROVAL= AP YEAR= 2019
NDA 212127 (pdf not found) INN (BUSULFAN) BUSULFAN (MEITHEAL) APPROVAL= AP YEAR= 2020
NDA 215102 (pdf not found) INN (BUSULFAN) BUSULFAN (EUGIA PHARMA) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 215235 (pdf not found) INN (BUSULFAN) BUSULFAN (PRINSTON INC) APPROVAL= AP YEAR= 2024