e-Drug3D

1548

TROGLITAZONE

DISCONTINUED

INN
TROGLITAZONE

cas 97322-87-7

CLASS

METABOLISM
ANTIDIABETIC
HYPOGLYCEMIC AGENTS
PPAR AGONIST

ROUTE (list)

ORAL

ATC code

A10BG01

PK parameters

VD 1202 LITER (65 KILOGRAM)
Cl 29.7 LITER / HOUR
PPB 99 PERCENT
t1/2 25 HOUR

Solubility

PRATICALLY INSOLUBLE IN WATER

Target

TARGET PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA (PPAR)

PDB
2VN0 (CYP2C8DH COMPLEXED WITH TROGLITAZONE)

Ligand code = TDZ (link to the list of PDB complexes)

Download experimental 3D coordinates of TDZ with added hydrogens

DrugCentral

Peroxisome proliferator-activated receptor gamma UNIPROT P37231 PPARG

Download SDF file

5-[[4-[(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione

Formula:
C24H27NO5S

Calculated chemical properties:

MW 441.54
NB_atoms 31
XLogP 4.37
PSA 86.884
NB_HD 2
NB_HA 6
fsp3 0.42
Lipinski(0=no;1=yes) 1

FDA
NDA 020719 (pdf not found) INN (TROGLITAZONE) PRELAY (SANKYO) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 020720 (pdf not found) INN (TROGLITAZONE) REZULIN (PFIZER PHARMS) APPROVAL= AP YEAR= 1997 NEWMOLECULARENTITY DISCONTINUED