1538

INN
FINGOLIMOD

(is an active metabolite)

IMMUNOMODULATING
IMMUNOSUPPRESSANT
MULTIPLE SCLEROSIS
FINGOLIMOD IS METABOLIZED BY SPHINGOSINE KINASE TO THE ACTIVE METABOLITE FINGOLIMOD-PHOSPHATE
FINGOLIMOD-PHOSPHATE INVOLVES REDUCTION OF LYMPHOCYTE MIGRATION INTO THE CENTRAL NERVOUS SYSTEM
S1P1 MODULATOR (NOT ANTAGONIST BUT AN AGONIST THAT CAUSES RECEPTOR DEGRADATION VERSUS RECYCLING TO CELL SURFACE)

-

F 93 PERCENT
VD 1200 LITER
Cl 6.3 LITER / HOUR
PPB 99.7 PERCENT
t1/2 180 HOUR

PDB
7VIF (CRYO-EM STRUCTURE OF GI COUPLED SPHINGOSINE 1-PHOSPHATE RECEPTOR BOUND WITH (S)-FTY720-P)

Ligand code = J89 (link to the list of PDB complexes)

Download experimental 3D coordinates of J89 with added hydrogens