e-Drug3D
1537
cas 1026258-58-1
CLASS
RESPIRATORY
CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)
PHOSPHODIESTERASE PDE4 INHIBITORS
ROFLUMILAST IS THREE TIMES MORE POTENT THAN ROFLUMILAST N-OXIDE AT INHIBITION OF THE PDE4 ENZYME IN VITRO THE PLASMA AUC OF ROFLUMILAST N-OXIDE ON AVERAGE IS ABOUT 10-FOLD GREATER THAN THE PLASMA AUC OF ROFLUMILAST
ROUTE (list)
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PK parameters
PPB 97 PERCENT
t1/2 30 HOUR
TARGET PDE4
PHOSPHODIESTERASE 4
Phosphodiesterase 4 UNIPROT P27815 PDE4A
Formula:
C17H14Cl2F2N2O4
Calculated chemical properties:
MW 419.20
NB_atoms 27
XLogP 4.16
PSA 71.919
NB_HD 1
NB_HA 6
fsp3 0.29
Lipinski(0=no;1=yes) 1
NB_atoms 27
XLogP 4.16
PSA 71.919
NB_HD 1
NB_HA 6
fsp3 0.29
Lipinski(0=no;1=yes) 1
FDA
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