e-Drug3D
1527
AXITINIB
INN
AXITINIB
cas 319460-85-0
CLASS
ANTINEOPLASTIC AGENT
PROTEIN KINASE INHIBITOR
RENAL CELL CARCINOMA
ROUTE (list)
ORAL
ATC code
L01EK01
PK parameters
F 58 PERCENT (5 MILLIGRAM)
VD 160 LITER (5 MILLIGRAM TWICE DAILY)
Cl 38 LITER / HOUR
PPB 99 PERCENT
t1/2 4.3 HOUR (5 MILLIGRAM TWICE DAILY)
Solubility
IN AQUEOUS MEDIA OVER THE RANGE PH 1.1 TO PH 7.8 IS IN EXCESS OF 0.2 MICROGRAM / MILLILITER
TARGET RECEPTOR TYROSINE KINASES
VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTORS
VEGFR-1
VEGFR-2
VEGFR-3
VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTORS
VEGFR-1
VEGFR-2
VEGFR-3
PDB
4WA9 (THE CRYSTAL STRUCTURE OF HUMAN ABL1 WILD TYPE KINASE DOMAIN IN COMPLEX WITH AXITINIB)
Ligand code = AXI (link to the list of PDB complexes)
Download experimental 3D coordinates of AXI with added hydrogens
Vascular endothelial growth factor receptor 1 UNIPROT P17948 FLT1
Vascular endothelial growth factor receptor 2 UNIPROT P35968 KDR
Formula:
C22H18N4OS
Calculated chemical properties:
MW 386.47
NB_atoms 28
XLogP 4.64
PSA 62.253
NB_HD 2
NB_HA 5
fsp3 0.05
Lipinski(0=no;1=yes) 1
NB_atoms 28
XLogP 4.64
PSA 62.253
NB_HD 2
NB_HA 5
fsp3 0.05
Lipinski(0=no;1=yes) 1