e-Drug3D

1523

cas 366789-02-8

CLASS

BLOOD
ANTITHROMBOTIC AGENTS
FACTOR XA INHIBITOR

ROUTE (list)

ORAL

PK parameters

F 90 PERCENT (10 MILLIGRAM)
VD 50 LITER
Cl 10 LITER / HOUR
PPB 93 PERCENT
t1/2 7 HOUR

TARGET XA FACTOR

PDB
2W26 (FACTOR XA IN COMPLEX WITH BAY59-7939)

Ligand code = RIV (link to the list of PDB complexes)

Download experimental 3D coordinates of RIV with added hydrogens

MW 435.88
NB_atoms 29
XLogP 2.52
PSA 89.349
NB_HD 1
NB_HA 8
fsp3 0.32
Lipinski(0=no;1=yes) 1

FDA
NDA 022406 (label) INN (RIVAROXABAN) XARELTO (JANSSEN PHARMS) APPROVAL= AP YEAR= 2011
NDA 202439 (label) INN (RIVAROXABAN) XARELTO (JANSSEN PHARMS) APPROVAL= AP YEAR= 2011
NDA 215859 (label) INN (RIVAROXABAN) XARELTO (JANSSEN PHARMS) APPROVAL= AP YEAR= 2021
NDA 212220 (pdf not found) INN (RIVAROXABAN) RIVAROXABAN (MYLAN PHARMS INC) APPROVAL= TA YEAR= 2022
NDA 208549 (pdf not found) INN (RIVAROXABAN) RIVAROXABAN (PRINSTON INC) APPROVAL= TA YEAR= 2024
NDA 208557 (pdf not found) INN (RIVAROXABAN) RIVAROXABAN (TARO) APPROVAL= AP YEAR= 2025
NDA 210301 (pdf not found) INN (RIVAROXABAN) RIVAROXABAN (ALEMBIC) APPROVAL= AP YEAR= 2025
NDA 208555 (pdf not found) INN (RIVAROXABAN) RIVAROXABAN (LUPIN LTD) APPROVAL= AP YEAR= 2025
NDA 208220 (pdf not found) INN (RIVAROXABAN) RIVAROXABAN (BRECKENRIDGE) APPROVAL= AP YEAR= 2025
NDA 208534 (pdf not found) INN (RIVAROXABAN) RIVAROXABAN (DR REDDYS) APPROVAL= AP YEAR= 2025
NDA 208543 (pdf not found) INN (RIVAROXABAN) RIVAROXABAN (INVAGEN PHARMS) APPROVAL= AP YEAR= 2025 DISCONTINUED
NDA 208544 (pdf not found) INN (RIVAROXABAN) RIVAROXABAN (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2025
NDA 213114 (pdf not found) INN (RIVAROXABAN) RIVAROXABAN (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2025
NDA 213348 (pdf not found) INN (RIVAROXABAN) RIVAROXABAN (SUNSHINE) APPROVAL= AP YEAR= 2025
NDA 216995 (pdf not found) INN (RIVAROXABAN) RIVAROXABAN (CHANGZHOU PHARM) APPROVAL= AP YEAR= 2025
NDA 217810 (pdf not found) INN (RIVAROXABAN) RIVAROXABAN (APOTEX) APPROVAL= AP YEAR= 2025
NDA 218107 (pdf not found) INN (RIVAROXABAN) RIVAROXABAN (BIOCON PHARMA) APPROVAL= AP YEAR= 2025
NDA 218117 (pdf not found) INN (RIVAROXABAN) RIVAROXABAN (SCIEGEN PHARMS INC) APPROVAL= AP YEAR= 2025
NDA 218445 (pdf not found) INN (RIVAROXABAN) RIVAROXABAN (INDOCO) APPROVAL= AP YEAR= 2025
NDA 218502 (pdf not found) INN (RIVAROXABAN) RIVAROXABAN (ALKEM LABS LTD) APPROVAL= AP YEAR= 2025
NDA 219332 (pdf not found) INN (RIVAROXABAN) RIVAROXABAN (ASCENT PHARMS INC) APPROVAL= AP YEAR= 2025