e-Drug3D

1522

INDACATEROL

DISCONTINUED

INN
INDACATEROL

cas 312753-06-3

CLASS

RESPIRATORY
BRONCHODILATOR
SELECTIVE BETA2 ADRENERGIC AGONIST
CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

ROUTE (list)

INHALATION

ATC code

R03AC18
R03AL04
R03AK14
R03AL12

PK parameters

F 44 PERCENT
VD 2459 LITER
Cl 21.05 LITER / HOUR
PPB 95 PERCENT
t1/2 85.7 HOUR

Solubility

VERY SLIGHTLY SOLUBLE IN WATER

Target

TARGET BETA-2-ADRENORECEPTOR

DrugCentral

Beta-2 adrenergic receptor UNIPROT P07550 ADRB2

Download SDF file

(R)-5-[2-(5,6-Diethylindan-2-ylamino)-1-hydroxyethyl]-8hydroxy-1H-quinolin-2-one

Formula:
C24H28N2O3

Calculated chemical properties:

MW 392.48
NB_atoms 29
XLogP 3.15
PSA 84.255
NB_HD 4
NB_HA 5
fsp3 0.38
Lipinski(0=no;1=yes) 1

FDA
NDA 022383 (label) INN (INDACATEROL MALEATE) ARCAPTA NEOHALER (NOVARTIS) APPROVAL= AP YEAR= 2011 NEWMOLECULARENTITY DISCONTINUED
NDA 207930 (label) INN (GLYCOPYRROLATE ; INDACATEROL MALEATE) UTIBRON (NOVARTIS) APPROVAL= AP YEAR= 2015 DISCONTINUED