e-Drug3D

152

cas 20830-75-5

CLASS

CARDIOVASCULAR
ANTI-ARRHYTHMIA AGENTS
CARDIOTONIC AGENTS
DIGOXIN IS EXTRACTED FROM THE LEAVES OF DIGITALIS LANATA
SODIUM-POTASSIUM ATPASE INHIBITOR

ROUTE (list)

INJECTION ORAL

PK parameters

F 70 PERCENT
Tmax 2 HOUR
VD 266 LITER (65 KILOGRAM)
Cl 6.6 LITER / HOUR (65 KILOGRAM)
PPB 25 PERCENT
t1/2 42 HOUR

TARGET SODIUM-POTASSIUM ATPASE

PDB
4RET (CRYSTAL STRUCTURE OF THE NA,K-ATPASE E2P-DIGOXIN COMPLEX WITH BOUND MAGNESIUM)

Ligand code = DGX (link to the list of PDB complexes)

Download experimental 3D coordinates of DGX with added hydrogens

MW 780.92
NB_atoms 55
XLogP 2.22
PSA 195.673
NB_HD 6
NB_HA 14
fsp3 0.93
Lipinski(0=no;1=yes) 0

FDA
NDA 083217 (pdf not found) INN (DIGOXIN) DIGOXIN (ABRAXIS PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 009330 (pdf not found) INN (DIGOXIN) LANOXIN (COVIS) APPROVAL= AP YEAR= 1954
NDA 083391 (pdf not found) INN (DIGOXIN) DIGOXIN (HIKMA) APPROVAL= AP YEAR= 1975
NDA 084386 (pdf not found) INN (DIGOXIN) DIGOXIN (WYETH AYERST) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 018118 (pdf not found) INN (DIGOXIN) LANOXICAPS (GLAXOSMITHKLINE LLC) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 040092 (pdf not found) INN (DIGOXIN) DIGOXIN PEDIATRIC (HOSPIRA) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 040093 (pdf not found) INN (DIGOXIN) DIGOXIN (HOSPIRA) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 020405 (pdf not found) INN (DIGOXIN) LANOXIN (ADVANZ PHARMA) APPROVAL= AP YEAR= 1997
NDA 040206 (pdf not found) INN (DIGOXIN) DIGOXIN (HOSPIRA) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 040282 (pdf not found) INN (DIGOXIN) DIGOXIN (RISING) APPROVAL= AP YEAR= 1999
NDA 076268 (pdf not found) INN (DIGOXIN) DIGOXIN (STEVENS J) APPROVAL= AP YEAR= 2002
NDA 040481 (pdf not found) INN (DIGOXIN) DIGOXIN (SANDOZ) APPROVAL= AP YEAR= 2003
NDA 076363 (pdf not found) INN (DIGOXIN) DIGOXIN (SUN PHARM INDS INC) APPROVAL= AP YEAR= 2003
NDA 021648 (pdf not found) INN (DIGOXIN) DIGOXIN (HIKMA) APPROVAL= AP YEAR= 2004
NDA 077002 (pdf not found) INN (DIGOXIN) DIGOXIN (HIKMA INTL PHARMS) APPROVAL= AP YEAR= 2007
NDA 078556 (pdf not found) INN (DIGOXIN) DIGOXIN (IMPAX LABS) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 213000 (pdf not found) INN (DIGOXIN) DIGOXIN (VISTAPHARM LLC) APPROVAL= AP YEAR= 2019
NDA 215307 (pdf not found) INN (DIGOXIN) DIGOXIN (NOVITIUM PHARMA) APPROVAL= AP YEAR= 2021
NDA 214982 (pdf not found) INN (DIGOXIN) DIGOXIN (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2022
NDA 215209 (pdf not found) INN (DIGOXIN) DIGOXIN (AMICI PHARMA) APPROVAL= AP YEAR= 2022