e-Drug3D
1504
CABAZITAXEL
INN
CABAZITAXEL
cas 183133-96-2
CLASS
ANTINEOPLASTIC
MICROTUBULE INHIBITOR
HORMONE-REFRACTORY METASTATIC PROSTATE CANCER
TAXANE CLASS
INHIBITION OF MITOTIC AND INTERPHASE CELLULAR FUNCTION
ROUTE (list)
INTRAVENOUS INJECTION
ATC code
L01CD04
PK parameters
VD 4864 LITER
Cl 48.5 LITER / HOUR
PPB 91 PERCENT
t1/2 95 HOUR
Solubility
PRACTICALLY INSOLUBLE IN WATER
TARGET MICROTUBULE
BINDS TO TUBULIN AND PROMOTES ITS ASSEMBLY INTO MICROTUBULES WHILE SIMULTANEOUSLY INHIBITING DISASSEMBLY
Tubulin beta UNIPROT P07437 TUBB
Formula:
C45H57NO14
Calculated chemical properties:
MW 835.92
NB_atoms 60
XLogP 4.57
PSA 165.574
NB_HD 3
NB_HA 15
fsp3 0.58
Lipinski(0=no;1=yes) 0
NB_atoms 60
XLogP 4.57
PSA 165.574
NB_HD 3
NB_HA 15
fsp3 0.58
Lipinski(0=no;1=yes) 0
FDA
NDA 201023 (pdf not found) INN (CABAZITAXEL) JEVTANA KIT (SANOFI AVENTIS US) APPROVAL= AP YEAR= 2010
NDA 207937 (pdf not found) INN (CABAZITAXEL) CABAZITAXEL (FRESENIUS KABI USA) APPROVAL= TA YEAR= 2019
NDA 207949 (pdf not found) INN (CABAZITAXEL) CABAZITAXEL (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 207693 (pdf not found) INN (CABAZITAXEL) CABAZITAXEL (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2022
NDA 207619 (pdf not found) INN (CABAZITAXEL) CABAZITAXEL (BRECKENRIDGE) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 207736 (pdf not found) INN (CABAZITAXEL) CABAZITAXEL (APOTEX) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 208715 (pdf not found) INN (CABAZITAXEL) CABAZITAXEL (SANDOZ) APPROVAL= TA YEAR= 2023
NDA 207718 (pdf not found) INN (CABAZITAXEL) CABAZITAXEL (DR REDDYS) APPROVAL= AP YEAR= 2023
NDA 207735 (pdf not found) INN (CABAZITAXEL) CABAZITAXEL (BPI LABS LLC) APPROVAL= TA YEAR= 2023
NDA 207381 (pdf not found) INN (CABAZITAXEL) CABAZITAXEL (MYLAN LABS LTD) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 207970 (pdf not found) INN (CABAZITAXEL) CABAZITAXEL (ACTAVIS) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 201023 (pdf not found) INN (CABAZITAXEL) JEVTANA KIT (SANOFI AVENTIS US) APPROVAL= AP YEAR= 2010
NDA 207937 (pdf not found) INN (CABAZITAXEL) CABAZITAXEL (FRESENIUS KABI USA) APPROVAL= TA YEAR= 2019
NDA 207949 (pdf not found) INN (CABAZITAXEL) CABAZITAXEL (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 207693 (pdf not found) INN (CABAZITAXEL) CABAZITAXEL (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2022
NDA 207619 (pdf not found) INN (CABAZITAXEL) CABAZITAXEL (BRECKENRIDGE) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 207736 (pdf not found) INN (CABAZITAXEL) CABAZITAXEL (APOTEX) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 208715 (pdf not found) INN (CABAZITAXEL) CABAZITAXEL (SANDOZ) APPROVAL= TA YEAR= 2023
NDA 207718 (pdf not found) INN (CABAZITAXEL) CABAZITAXEL (DR REDDYS) APPROVAL= AP YEAR= 2023
NDA 207735 (pdf not found) INN (CABAZITAXEL) CABAZITAXEL (BPI LABS LLC) APPROVAL= TA YEAR= 2023
NDA 207381 (pdf not found) INN (CABAZITAXEL) CABAZITAXEL (MYLAN LABS LTD) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 207970 (pdf not found) INN (CABAZITAXEL) CABAZITAXEL (ACTAVIS) APPROVAL= AP YEAR= 2024 DISCONTINUED