e-Drug3D
1503
LURASIDONE
INN
LURASIDONE
cas 367514-87-2
CLASS
NERVOUS SYSTEM
ANTIPSYCHOTIC
SCHIZOPHRENIA
CLASS OF BENZISOTHIAZOL DERIVATIVES
ANTAGONIST
ROUTE (list)
ORAL
ATC code
N05AE05
PK parameters
VD 6173 LITER (40 MILLIGRAM)
Cl 234 LITER / HOUR (40 MILLIGRAM)
PPB 99 PERCENT
t1/2 18 HOUR (40 MILLIGRAM)
Solubility
VERY SLIGHTLY SOLUBLE IN WATER
TARGET DOPAMINE D2 ANTAGONIST (KI=0.994 NANOMOLAR)
5-HT2A ANTAGONIST (KI=0.47 NANOMOLAR)
5-HT7 ANTAGONIST (KI=0.495 NANOMOLAR)
ALPHA2C-ADRENERGIC RECEPTOR ANTAGONIST (KI=10.8 NANOMOLAR)
5-HT1A RECEPTOR PARTIAL AGONIST (KI=6.38 NANOMOLAR)
ALPHA2A ADRENERGIC RECEPTORS ANTAGONIST (KI=40.7 NM)
D(2) dopamine receptor UNIPROT P14416 DRD2
5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A
Formula:
C28H36N4O2S
Calculated chemical properties:
MW 492.68
NB_atoms 35
XLogP 4.26
PSA 57.364
NB_HD 0
NB_HA 6
fsp3 0.68
Lipinski(0=no;1=yes) 1
NB_atoms 35
XLogP 4.26
PSA 57.364
NB_HD 0
NB_HA 6
fsp3 0.68
Lipinski(0=no;1=yes) 1
FDA
NDA 200603 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LATUDA (SUNOVION PHARMS INC) APPROVAL= AP YEAR= 2010
NDA 207948 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (PAR PHARM INC) APPROVAL= TA YEAR= 2017
NDA 208002 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (AMNEAL PHARMS CO) APPROVAL= AP YEAR= 2019
NDA 208031 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (LUPIN LTD) APPROVAL= AP YEAR= 2019
NDA 208058 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (HERITAGE PHARMA AVET) APPROVAL= AP YEAR= 2019
NDA 208066 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (SUN PHARM) APPROVAL= AP YEAR= 2019
NDA 208028 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (INVAGEN PHARMS) APPROVAL= AP YEAR= 2019
NDA 208049 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2019
NDA 208055 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (TORRENT) APPROVAL= AP YEAR= 2019
NDA 208052 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2019
NDA 208060 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 212091 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2020
NDA 208016 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (WATSON LABS TEVA) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 213248 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (ALEMBIC) APPROVAL= AP YEAR= 2021
NDA 208047 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (DR REDDYS) APPROVAL= AP YEAR= 2021
NDA 208037 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (MSN) APPROVAL= AP YEAR= 2022
NDA 212244 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (ALKEM LABS LTD) APPROVAL= AP YEAR= 2022
NDA 208045 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2023
NDA 212124 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2023
NDA 210388 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (JUBILANT GENERICS) APPROVAL= AP YEAR= 2024
NDA 218174 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (ANNORA PHARMA) APPROVAL= AP YEAR= 2024
NDA 200603 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LATUDA (SUNOVION PHARMS INC) APPROVAL= AP YEAR= 2010
NDA 207948 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (PAR PHARM INC) APPROVAL= TA YEAR= 2017
NDA 208002 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (AMNEAL PHARMS CO) APPROVAL= AP YEAR= 2019
NDA 208031 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (LUPIN LTD) APPROVAL= AP YEAR= 2019
NDA 208058 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (HERITAGE PHARMA AVET) APPROVAL= AP YEAR= 2019
NDA 208066 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (SUN PHARM) APPROVAL= AP YEAR= 2019
NDA 208028 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (INVAGEN PHARMS) APPROVAL= AP YEAR= 2019
NDA 208049 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2019
NDA 208055 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (TORRENT) APPROVAL= AP YEAR= 2019
NDA 208052 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2019
NDA 208060 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 212091 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2020
NDA 208016 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (WATSON LABS TEVA) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 213248 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (ALEMBIC) APPROVAL= AP YEAR= 2021
NDA 208047 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (DR REDDYS) APPROVAL= AP YEAR= 2021
NDA 208037 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (MSN) APPROVAL= AP YEAR= 2022
NDA 212244 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (ALKEM LABS LTD) APPROVAL= AP YEAR= 2022
NDA 208045 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2023
NDA 212124 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2023
NDA 210388 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (JUBILANT GENERICS) APPROVAL= AP YEAR= 2024
NDA 218174 (pdf not found) INN (LURASIDONE HYDROCHLORIDE) LURASIDONE HYDROCHLORIDE (ANNORA PHARMA) APPROVAL= AP YEAR= 2024