e-Drug3D

1502

CEFTAROLINE

INN
CEFTAROLINE

(has an active metabolite)

cas 402741-13-3

CLASS

ANTIINFECTIVE
ANTIBIOTIC
ANTIBACTERIAL
CEPHALOSPORINS

ROUTE (list)

INTRAVENOUS

ATC code

J01DI02

PK parameters

VD 19.9 LITER (600 MILLIGRAM)
Cl 9.58 LITER / HOUR (600 MILLIGRAM)
PPB 20 PERCENT
t1/2 1.6 HOUR (600 MILLIGRAM)

Solubility

WATER SOLUBLE PRODRUG OF CEFTAROLINE

Target

TARGET PENICILLIN-BINDING PROTEIN 1B
PENICILLIN-BINDING PROTEIN 1A
PENICILLIN-BINDING PROTEIN 2A

DrugCentral

Bacterial penicillin-binding protein UNIPROT P02918 mrcA

Download SDF file

Pyridinium, 4-[2-[[(6R,7R)-2-carboxy-7-[[(2Z)-2-(ethoxyimino)-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]thio]-4-thiazolyl]-1-methyl-

Formula:
C22H22N8O8PS4

Calculated chemical properties:

MW 682.70
NB_atoms 43
XLogP -1.38
PSA 197.906
NB_HD 2
NB_HA 15
fsp3 0.27
Lipinski(0=no;1=yes) 0

FDA
NDA 200327 (pdf not found) INN (CEFTAROLINE FOSAMIL) TEFLARO (ABBVIE) APPROVAL= AP YEAR= 2010 NEWMOLECULARENTITY
NDA 208075 (pdf not found) INN (CEFTAROLINE FOSAMIL) CEFTAROLINE FOSAMIL (APOTEX) APPROVAL= AP YEAR= 2021 DISCONTINUED