e-Drug3D

1500

cas 162359-55-9

CLASS

IMMUNOMODULATING
IMMUNOSUPPRESSANT
MULTIPLE SCLEROSIS
FINGOLIMOD IS METABOLIZED BY SPHINGOSINE KINASE TO THE ACTIVE METABOLITE FINGOLIMOD-PHOSPHATE
FINGOLIMOD-PHOSPHATE INVOLVES REDUCTION OF LYMPHOCYTE MIGRATION INTO THE CENTRAL NERVOUS SYSTEM
S1P1 MODULATOR (RECEPTOR DEGRADATION VERSUS RECYCLING TO CELL SURFACE)

ROUTE (list)

ORAL

PK parameters

F 93 PERCENT
PPB 99.7 PERCENT

MW 307.46
NB_atoms 22
XLogP 3.20
PSA 63.93
NB_HD 4
NB_HA 3
fsp3 0.68
Lipinski(0=no;1=yes) 1

FDA
NDA 022527 (pdf not found) INN (FINGOLIMOD HYDROCHLORIDE) GILENYA (NOVARTIS) APPROVAL= AP YEAR= 2010
NDA 207965 (pdf not found) INN (FINGOLIMOD) FINGOLIMOD (PAR PHARM INC) APPROVAL= TA YEAR= 2017
NDA 207979 (pdf not found) INN (FINGOLIMOD HYDROCHLORIDE) FINGOLIMOD HYDROCHLORIDE (BIOCON LTD) APPROVAL= AP YEAR= 2019
NDA 208014 (pdf not found) INN (FINGOLIMOD HYDROCHLORIDE) FINGOLIMOD HYDROCHLORIDE (SUN PHARM) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 208559 (pdf not found) INN (FINGOLIMOD) FINGOLIMOD (MSN LABS PVT LTD) APPROVAL= TA YEAR= 2020
NDA 207971 (pdf not found) INN (FINGOLIMOD HYDROCHLORIDE) FINGOLIMOD HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 207985 (pdf not found) INN (FINGOLIMOD HYDROCHLORIDE) FINGOLIMOD HYDROCHLORIDE (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2020
NDA 207991 (pdf not found) INN (FINGOLIMOD HYDROCHLORIDE) FINGOLIMOD HYDROCHLORIDE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2020
NDA 208004 (pdf not found) INN (FINGOLIMOD HYDROCHLORIDE) FINGOLIMOD HYDROCHLORIDE (ALKEM LABS LTD) APPROVAL= AP YEAR= 2020
NDA 208008 (pdf not found) INN (FINGOLIMOD HYDROCHLORIDE) FINGOLIMOD HYDROCHLORIDE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2020
NDA 207933 (pdf not found) INN (FINGOLIMOD HYDROCHLORIDE) FINGOLIMOD HYDROCHLORIDE (HETERO LABS LTD V) APPROVAL= AP YEAR= 2020
NDA 207993 (pdf not found) INN (FINGOLIMOD HYDROCHLORIDE) FINGOLIMOD HYDROCHLORIDE (APOTEX) APPROVAL= AP YEAR= 2020
NDA 207994 (pdf not found) INN (FINGOLIMOD HYDROCHLORIDE) FINGOLIMOD HYDROCHLORIDE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2020
NDA 207939 (pdf not found) INN (FINGOLIMOD HYDROCHLORIDE) FINGOLIMOD HYDROCHLORIDE (HEC PHARM CO LTD) APPROVAL= AP YEAR= 2021
NDA 207940 (pdf not found) INN (FINGOLIMOD) FINGOLIMOD (STANDARD CHEM AND PHARM CO LTD) APPROVAL= TA YEAR= 2021
NDA 208000 (pdf not found) INN (FINGOLIMOD HYDROCHLORIDE) FINGOLIMOD HYDROCHLORIDE (DR REDDYS) APPROVAL= AP YEAR= 2021
NDA 208005 (pdf not found) INN (FINGOLIMOD HYDROCHLORIDE) FINGOLIMOD HYDROCHLORIDE (MYLAN) APPROVAL= AP YEAR= 2021
NDA 212152 (pdf not found) INN (FINGOLIMOD HYDROCHLORIDE) FINGOLIMOD HYDROCHLORIDE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 214962 (pdf not found) INN (FINGOLIMOD LAURYL SULFATE) TASCENSO ODT (CYCLE) APPROVAL= AP YEAR= 2021
NDA 208003 (pdf not found) INN (FINGOLIMOD HYDROCHLORIDE) FINGOLIMOD HYDROCHLORIDE (PRINSTON INC) APPROVAL= AP YEAR= 2022
NDA 210252 (pdf not found) INN (FINGOLIMOD HYDROCHLORIDE) FINGOLIMOD HYDROCHLORIDE (BIONPHARMA) APPROVAL= AP YEAR= 2023
NDA 207945 (pdf not found) INN (FINGOLIMOD HYDROCHLORIDE) FINGOLIMOD HYDROCHLORIDE (EZRA VENTURES) APPROVAL= AP YEAR= 2023
NDA 207983 (pdf not found) INN (FINGOLIMOD HYDROCHLORIDE) FINGOLIMOD HYDROCHLORIDE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2024