e-Drug3D

1498

ULIPRISTAL ACETATE

INN
ULIPRISTAL ACETATE

(has an active metabolite)

cas 126784-99-4

CLASS

GENITO
PROGESTERONE PARTIAL AGONIST AND ANTAGONIST EMERGENCY CONTRACEPTIVE

ROUTE (list)

ORAL

ATC code

G03AD02
G03XB02

PK parameters

Tmax 0.9 HOUR
Cl 76.8 LITER / HOUR
PPB 94 PERCENT
t1/2 32 HOUR

Target

TARGET PROGESTERONE RECEPTOR

PDB
4OAR (PROGESTERONE RECEPTOR WITH BOUND ULIPRISTAL ACETATE AND A PEPTIDE FROM THE CO-REPRESSOR SMRT)

Ligand code = 2S0 (link to the list of PDB complexes)

Download experimental 3D coordinates of 2S0 with added hydrogens

DrugCentral

Progesterone receptor UNIPROT P06401 PGR

Download SDF file

19-Norpregna-4,9-diene-3,20-dione,17-(acetyloxy)-11-[4-(dimethylamino)phenyl]-,(11beta)-

Formula:
C30H37NO4

Calculated chemical properties:

MW 475.61
NB_atoms 35
XLogP 5.54
PSA 59.478
NB_HD 0
NB_HA 5
fsp3 0.57
Lipinski(0=no;1=yes) 0

FDA
NDA 022474 (label) INN (ULIPRISTAL ACETATE) ELLA (LAB HRA PHARMA) APPROVAL= AP YEAR= 2010
NDA 207952 (pdf not found) INN (ULIPRISTAL ACETATE) LOGILIA (TEVA PHARMS USA) APPROVAL= AP YEAR= 2017