e-Drug3D

1496

ALCAFTADINE

INN
ALCAFTADINE

(has an active metabolite)

cas 147084-10-4

CLASS

RESPIRATORY
ALLERGIC CONJUNCTIVITIS
H1 HISTAMINE RECEPTOR ANTAGONIST

ROUTE (list)

OPHTHALMIC

ATC code

S01GX11

PK parameters

Tmax 0.25 HOUR
PPB 39.2 PERCENT

Target

TARGET H1 HISTAMINE RECEPTOR

DrugCentral

Histamine H1 receptor UNIPROT P35367 HRH1

Download SDF file

5H-Imidazo[2,1-b][3]benzazepine-3-carboxaldehyde, 6,11-dihydro-11-(1-methyl-4-piperidinylidene)-

Formula:
C19H21N3O

Calculated chemical properties:

MW 307.39
NB_atoms 23
XLogP 2.78
PSA 34.574
NB_HD 0
NB_HA 4
fsp3 0.37
Lipinski(0=no;1=yes) 1

FDA
NDA 022134 (label) INN (ALCAFTADINE) LASTACAFT (ABBVIE) APPROVAL= AP YEAR= 2010
NDA 210659 (pdf not found) INN (ALCAFTADINE) ALCAFTADINE (EUGIA PHARMA) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 209706 (pdf not found) INN (ALCAFTADINE) ALCAFTADINE (GLAND) APPROVAL= AP YEAR= 2024
NDA 209290 (pdf not found) INN (ALCAFTADINE) ALCAFTADINE (ALEMBIC) APPROVAL= AP YEAR= 2024