e-Drug3D

1492

TOLVAPTAN

INN
TOLVAPTAN

cas 150683-30-0

CLASS

CARDIOVASCULAR
DIURETIC
VASOPRESSIN V2-RECEPTOR ANTAGONIST
HYPERVOLEMIC AND EUVOLEMIC HYPONATREMIA

ROUTE (list)

ORAL

ATC code

C03XA01

PK parameters

VD 195 LITER (65 KILOGRAM)
Cl 15.6 LITER / HOUR (65 KILOGRAM)
PPB 99 PERCENT
t1/2 12 HOUR

Target

TARGET ARGININE VASOPRESSIN RECEPTOR 2

DrugCentral

Vasopressin V2 receptor UNIPROT P30518 AVPR2

Download SDF file

N-(4-{[(5R)-7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl}-3-methylphenyl)-2-methylbenzamide

Formula:
C26H25ClN2O3

Calculated chemical properties:

MW 448.93
NB_atoms 32
XLogP 5.68
PSA 54.424
NB_HD 2
NB_HA 5
fsp3 0.23
Lipinski(0=no;1=yes) 0

FDA
NDA 022275 (label) INN (TOLVAPTAN) SAMSCA (OTSUKA) APPROVAL= AP YEAR= 2009
NDA 204441 (label) INN (TOLVAPTAN) JYNARQUE (OTSUKA) APPROVAL= AP YEAR= 2018 NEWAPPLICATION
NDA 207605 (pdf not found) INN (TOLVAPTAN) TOLVAPTAN (APOTEX) APPROVAL= AP YEAR= 2020
NDA 211891 (pdf not found) INN (TOLVAPTAN) TOLVAPTAN (ALKEM LABS LTD) APPROVAL= AP YEAR= 2020
NDA 205646 (pdf not found) INN (TOLVAPTAN) TOLVAPTAN (HETERO LABS LTD V) APPROVAL= AP YEAR= 2021
NDA 206119 (pdf not found) INN (TOLVAPTAN) TOLVAPTAN (PH HEALTH) APPROVAL= AP YEAR= 2022
NDA 216949 (pdf not found) INN (TOLVAPTAN) TOLVAPTAN (MSN) APPROVAL= AP YEAR= 2023
NDA 216063 (pdf not found) INN (TOLVAPTAN) TOLVAPTAN (LUPIN LTD) APPROVAL= AP YEAR= 2025