e-Drug3D

1491

TENOFOVIR

INN
TENOFOVIR

cas 147127-20-6

CLASS

ANTIINFECTIVE
ANTIVIRAL
ANTIRETROVIRAL
NUCLEOTIDE ANALOG HIV-1 REVERSE TRANSCRIPTASE INHIBITOR AND
HBV REVERSE TRANSCRIPTASE INHIBITOR
CHRONIC HEPATITIS B IN ADULTS

ROUTE (list)

ATC code

J05AR06
J05AR08
J05AR12
J05AR27
J05AR24
J05AR11
J05AF07
J05AR03

PK parameters

F 25 PERCENT
VD 84.5 LITER (65 KILOGRAM)
Cl 3.4 LITER / HOUR (EQN)
PPB 7 PERCENT
t1/2 17 HOUR

Target

TARGET HIV REVERSE TRANSCRIPTASE

PDB
8BVS (CRYO-EM STRUCTURE OF RAT SLC22A6 BOUND TO TENOFOVIR)

Ligand code = TFO (link to the list of PDB complexes)

Download experimental 3D coordinates of TFO with added hydrogens

DrugCentral

Reverse transcriptase,RNaseH UNIPROT Q72547 pol

Download SDF file

[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid

Formula:
C9H14N5O4P

Calculated chemical properties:

MW 285.21
NB_atoms 19
XLogP -1.32
PSA 124.294
NB_HD 2
NB_HA 9
fsp3 0.44
Lipinski(0=no;1=yes) 1

FDA
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