e-Drug3D

1485

CARGLUMIC ACID

INN
CARGLUMIC ACID

cas 1188-38-1

CLASS

HYPERAMMONAEMIA
CARBAMOYL PHOSPHATE SYNTHETASE 1 (CPS 1) AGONIST IN LIVER MITOCHONDRIA
DEFICIENCY OF THE HEPATIC ENZYME N-ACETYLGLUTAMATE SYNTHASE (NAGS)
STRUCTURAL ANALOGUE OF N-ACETYLGLUTAMATE (NAG)

ROUTE (list)

ORAL

ATC code

A16AA05

PK parameters

VD 2657 LITER
Cl 342 LITER / HOUR
t1/2 5.6 HOUR

Solubility

SOLUBLE IN BOILING WATER AND SLIGHTLY SOLUBLE IN COLD WATER

Target

TARGET CARBAMOYL PHOSPHATE SYNTHETASE 1 (CPS 1)

DrugCentral

Carbamoyl-phosphate synthase ammonia, mitochondrial UNIPROT P31327 CPS1

Download SDF file

L-Glutamic acid, N-(aminocarbonyl)-

Formula:
C6H10N2O5

Calculated chemical properties:

MW 188.14
NB_atoms 13
XLogP -3.70
PSA 124.362
NB_HD 3
NB_HA 7
fsp3 0.50
Lipinski(0=no;1=yes) 1

FDA
NDA 022562 (label) INN (CARGLUMIC ACID) CARBAGLU (RECORDATI RARE) APPROVAL= AP YEAR= 2010
NDA 213729 (pdf not found) INN (CARGLUMIC ACID) CARGLUMIC ACID (NOVITIUM PHARMA) APPROVAL= AP YEAR= 2021
NDA 213395 (pdf not found) INN (CARGLUMIC ACID) CARGLUMIC ACID (NAVINTA LLC) APPROVAL= AP YEAR= 2022