e-Drug3D
1481
PRALATREXATE
INN
PRALATREXATE
cas 146464-95-1
CLASS
ANTINEOPLASTIC
FOLIC ACID ANALOGUES
FOLATE ANALOG METABOLIC INHIBITOR
LYMPHOMA
ROUTE (list)
INTRAVENOUS INJECTION
ATC code
L01BA05
PK parameters
VD 37 LITER
Cl 11.46 LITER / HOUR
PPB 67 PERCENT
t1/2 15 HOUR
Solubility
SOLUBLE IN AQUEOUS SOLUTIONS AT PH 6.5 OR HIGHER
TARGET DIHYDROFOLATE REDUCTASE
FOLYLPOLYGLUTAMYL SYNTHETASE
Dihydrofolate reductase UNIPROT P00374 DHFR
Formula:
C23H23N7O5
Calculated chemical properties:
MW 475.47
NB_atoms 35
XLogP -1.69
PSA 187.243
NB_HD 5
NB_HA 12
fsp3 0.26
Lipinski(0=no;1=yes) 0
NB_atoms 35
XLogP -1.69
PSA 187.243
NB_HD 5
NB_HA 12
fsp3 0.26
Lipinski(0=no;1=yes) 0
FDA
NDA 022468 (label) INN (PRALATREXATE) FOLOTYN (ACROTECH BIOPHARMA) APPROVAL= AP YEAR= 2009 NEWMOLECULARENTITY
NDA 206167 (pdf not found) INN (PRALATREXATE) PRALATREXATE (TEVA PHARMS USA INC) APPROVAL= TA YEAR= 2016
NDA 206183 (pdf not found) INN (PRALATREXATE) PRALATREXATE (DR REDDYS) APPROVAL= AP YEAR= 2025
NDA 022468 (label) INN (PRALATREXATE) FOLOTYN (ACROTECH BIOPHARMA) APPROVAL= AP YEAR= 2009 NEWMOLECULARENTITY
NDA 206167 (pdf not found) INN (PRALATREXATE) PRALATREXATE (TEVA PHARMS USA INC) APPROVAL= TA YEAR= 2016
NDA 206183 (pdf not found) INN (PRALATREXATE) PRALATREXATE (DR REDDYS) APPROVAL= AP YEAR= 2025