e-Drug3D

148

cas 57-83-0

CLASS

GENITO
CONTRACEPTIVES
PROGESTINS

ROUTE (list)

INJECTION INTRAUTERINE ORAL VAGINAL

PK parameters

Tmax 1.7 HOUR
Cl 104.6 LITER / HOUR
PPB 97 PERCENT
t1/2 34.8 HOUR

TARGET PROGESTERONE RECEPTOR

PDB
4L1W (CRYSTAL STRUCTUER OF HUMAN 3-ALPHA HYDROXYSTEROID DEHYDROGENASE TYPE 3 IN COMPLEX WITH NADP+ AND PROGESTERONE)

Ligand code = STR (link to the list of PDB complexes)

Download experimental 3D coordinates of STR with added hydrogens

MW 314.45
NB_atoms 23
XLogP 4.72
PSA 33.524
NB_HD 0
NB_HA 2
fsp3 0.81
Lipinski(0=no;1=yes) 1

FDA
NDA 009238 (pdf not found) INN (PROGESTERONE) PROGESTERONE (LILLY) APPROVAL= AP YEAR= 1974 DISCONTINUED
NDA 017553 (pdf not found) INN (PROGESTERONE) PROGESTASERT (ALZA) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 017362 (label) INN (PROGESTERONE) PROGESTERONE (ACTAVIS LABS UT INC) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 020701 (label) INN (PROGESTERONE) CRINONE (ABBVIE) APPROVAL= AP YEAR= 1997
NDA 020756 (pdf not found) INN (PROGESTERONE) CRINONE (WATSON LABS INC) APPROVAL= AP YEAR= 1997
NDA 019781 (label) INN (PROGESTERONE) PROMETRIUM (ACERTIS PHARMS) APPROVAL= AP YEAR= 1998
NDA 020843 (label) INN (PROGESTERONE) PROMETRIUM (VIRTUS PHARMS) APPROVAL= AP YEAR= 1998 NEWAPPLICATION
NDA 075906 (label) INN (PROGESTERONE) PROGESTERONE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2001
NDA 022057 (label) INN (PROGESTERONE) ENDOMETRIN (FERRING) APPROVAL= AP YEAR= 2007
NDA 090845 (pdf not found) INN (PROGESTERONE) PROGESTERONE (AM REGENT) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 091033 (pdf not found) INN (PROGESTERONE) PROGESTERONE (HIKMA FARMACEUTICA) APPROVAL= AP YEAR= 2010
NDA 202121 (pdf not found) INN (PROGESTERONE) PROGESTERONE (TEVA PHARMS) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 200456 (pdf not found) INN (PROGESTERONE) PROGESTERONE (SOFGEN PHARMS) APPROVAL= AP YEAR= 2012
NDA 200900 (pdf not found) INN (PROGESTERONE) PROGESTERONE (BIONPHARMA) APPROVAL= AP YEAR= 2013
NDA 208801 (pdf not found) INN (PROGESTERONE) PROGESTERONE (DR REDDYS) APPROVAL= AP YEAR= 2017
NDA 205229 (pdf not found) INN (PROGESTERONE) PROGESTERONE (XIROMED) APPROVAL= AP YEAR= 2017
NDA 207724 (pdf not found) INN (PROGESTERONE) PROGESTERONE (AMNEAL PHARMS NY) APPROVAL= AP YEAR= 2017
NDA 210132 (label) INN (ESTRADIOL ; PROGESTERONE) BIJUVA (MAYNE PHARMA) APPROVAL= AP YEAR= 2018
NDA 210965 (pdf not found) INN (PROGESTERONE) PROGESTERONE (EUGIA PHARMA) APPROVAL= AP YEAR= 2018
NDA 211285 (pdf not found) INN (PROGESTERONE) PROGESTERONE (EUGIA PHARMA) APPROVAL= AP YEAR= 2018
NDA 201110 (label) INN (PROGESTERONE) MILPROSA (FERRING PHARMS INC) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 214293 (pdf not found) INN (ESTRADIOL ; PROGESTERONE) ESTRADIOL AND PROGESTERONE (AMNEAL PHARMS) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 215634 (pdf not found) INN (PROGESTERONE) PROGESTERONE (XIROMED) APPROVAL= AP YEAR= 2022
NDA 217707 (pdf not found) INN (PROGESTERONE) PROGESTERONE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2023 DISCONTINUED