1477

INN
ASENAPINE

ANTIPSYCHOTICS
5-HT2A RECEPTOR AGONIST
NERVOUS SYSTEM
SCHIZOPHRENIA
BIPOLAR DISORDER
HIGH AFFINITY FOR SEROTONIN 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5, 5-HT6, AND 5-HT7 RECEPTORS (KI VALUES OF 2.5, 4.0, 0.06, 0.16, 0.03, 1.6, 0.25, AND 0.13 NM), DOPAMINE D2, D3, D4, AND D1 RECEPTORS (KI VALUES OF 1.3, 0.42, 1.1, AND 1.4 NM), ALPHA1 AND ALPHA2-ADRENERGIC RECEPTORS (KI VALUES OF 1.2 AND 1.2 NM), AND HISTAMINE H1 RECEPTORS (KI VALUE 1.0 NM), AND MODERATE AFFINITY FOR H2 RECEPTORS (KI VALUE OF 6.2 NM)

SUBLINGUAL TRANSDERMAL

F 35 PERCENT (5 MILLIGRAM)
VD 1462 LITER (65 KILOGRAM)
Cl 52 LITER / HOUR
PPB 95 PERCENT
t1/2 24 HOUR