e-Drug3D

1473

BESIFLOXACIN

INN
BESIFLOXACIN

cas 141388-76-3

CLASS

ANTIBIOTIC
ANTIBACTERIAL
ANTI-INFECTIVES
FOURTH-GENERATION FLUOROQUINOLONE ANTIBIOTIC
ANTIINFECTIVES
DNA GYRASE INHIBITOR
TOPOISOMERASE IV INHIBITOR

ROUTE (list)

OPHTHALMIC

ATC code

S01AE08

PK parameters

t1/2 7 HOUR

Target

TARGET DNA GYRASE
TOPOISOMERASE IV

Topoisomerase IV UNIPROT P0AFI2 parC

DNA gyrase UNIPROT P0AES4 gyrA

Download SDF file

7-[(3R) -3-aminoazepam- 1-yl]- 8-chloro- 1-cyclopropyl- 6-fluoro- 4-oxo- 1,4- dihydroquinoline- 3-carboxylic acid

Formula:
C19H21ClFN3O3

Calculated chemical properties:

MW 392.83
NB_atoms 27
XLogP 1.81
PSA 82.3
NB_HD 2
NB_HA 6
fsp3 0.47
Lipinski(0=no;1=yes) 1

FDA
NDA 022308 (label) INN (BESIFLOXACIN HYDROCHLORIDE) BESIVANCE (BAUSCH AND LOMB) APPROVAL= AP YEAR= 2009 NEWMOLECULARENTITY