e-Drug3D

1455

cas 175481-36-4

CLASS

NERVOUS SYSTEM
ANTIEPILEPTIC
PARTIAL-ONSET SEIZURES
FUNCTIONALIZED AMINO ACID
VOLTAGE GATED SODIUM CHANNELS INHIBITOR

ROUTE (list)

ORAL INTRAVENOUS

PK parameters

F 100 PERCENT
VD 39 LITER (65 KILOGRAM)
Cl 2 LITER / HOUR (EQN)
PPB 15 PERCENT
t1/2 13 HOUR

TARGET VOLTAGE GATED SODIUM CHANNELS
COLLAPSIN RESPONSE MEDIATOR PROTEIN-2 (CRMP-2)

PDB
8S9B (CRYO-EM STRUCTURE OF NAV1.7 WITH LCM)

Ligand code = LQO (link to the list of PDB complexes)

Download experimental 3D coordinates of LQO with added hydrogens

MW 250.29
NB_atoms 18
XLogP 0.45
PSA 64.221
NB_HD 2
NB_HA 5
fsp3 0.38
Lipinski(0=no;1=yes) 1

FDA
NDA 022253 (label) INN (LACOSAMIDE) VIMPAT (UCB INC) APPROVAL= AP YEAR= 2008
NDA 022254 (label) INN (LACOSAMIDE) VIMPAT (UCB INC) APPROVAL= AP YEAR= 2008
NDA 022255 (label) INN (LACOSAMIDE) VIMPAT (UCB INC) APPROVAL= AP YEAR= 2010
NDA 205026 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (MYLAN PHARMS INC) APPROVAL= AP YEAR= 2016 OBSOLETE
NDA 204980 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (GLENMARK PHARMS LTD) APPROVAL= TA YEAR= 2016
NDA 204999 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (TEVA PHARMS USA) APPROVAL= TA YEAR= 2017
NDA 204857 (label) INN (LACOSAMIDE) LACOSAMIDE (AMNEAL PHARMS) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 204974 (label) INN (LACOSAMIDE) LACOSAMIDE (ALEMBIC) APPROVAL= AP YEAR= 2022
NDA 205011 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 206355 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (APOTEX) APPROVAL= AP YEAR= 2022
NDA 205006 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2022
NDA 204921 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (MSN LABS PVT LTD) APPROVAL= AP YEAR= 2022
NDA 205031 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (SUN PHARM) APPROVAL= AP YEAR= 2022
NDA 214672 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (ALKEM LABS LTD) APPROVAL= AP YEAR= 2022
NDA 214695 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (ALKEM LABS LTD) APPROVAL= AP YEAR= 2022
NDA 204787 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (HETERO LABS LTD V) APPROVAL= AP YEAR= 2022
NDA 205237 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (SCIEGEN PHARMS INC) APPROVAL= AP YEAR= 2022
NDA 208308 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (INDOCO) APPROVAL= AP YEAR= 2022
NDA 209301 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (HETERO LABS LTD III) APPROVAL= AP YEAR= 2022
NDA 209465 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2022
NDA 214301 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (INDOCO) APPROVAL= AP YEAR= 2022
NDA 214677 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2022
NDA 214567 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (APOTEX) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 215628 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (GLAND) APPROVAL= AP YEAR= 2022
NDA 216151 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (NOVITIUM PHARMA) APPROVAL= AP YEAR= 2022
NDA 216335 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (ASPIRO) APPROVAL= AP YEAR= 2022
NDA 204855 (label) INN (LACOSAMIDE) LACOSAMIDE (ACTAVIS LABS FL INC) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 204994 (label) INN (LACOSAMIDE) LACOSAMIDE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2023
NDA 204947 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 215979 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (MSN) APPROVAL= AP YEAR= 2023
NDA 216185 (label) INN (LACOSAMIDE) MOTPOLY XR (AUCTA) APPROVAL= AP YEAR= 2023
NDA 216461 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (MEDLEY PHARMS) APPROVAL= AP YEAR= 2023
NDA 215379 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (MSN) APPROVAL= AP YEAR= 2023
NDA 216670 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (APOTEX) APPROVAL= AP YEAR= 2023
NDA 204839 (label) INN (LACOSAMIDE) LACOSAMIDE (AMNEAL PHARMS) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 208466 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2024
NDA 209224 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2024
NDA 215154 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2024
NDA 216806 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (HIKMA) APPROVAL= AP YEAR= 2024
NDA 217311 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (HAINAN POLY) APPROVAL= AP YEAR= 2024
NDA 217718 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (DR REDDYS) APPROVAL= AP YEAR= 2024
NDA 218014 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (KANCHAN HLTHCARE) APPROVAL= AP YEAR= 2024
NDA 213109 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (UNICHEM) APPROVAL= AP YEAR= 2024
NDA 214960 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (SOMERSET THERAPS LLC) APPROVAL= AP YEAR= 2024
NDA 218464 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (ACELLA) APPROVAL= AP YEAR= 2024
NDA 218706 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (WESTMINSTER PHARMS) APPROVAL= AP YEAR= 2025
NDA 219699 (pdf not found) INN (LACOSAMIDE) LACOSAMIDE (AJENAT PHARMS) APPROVAL= AP YEAR= 2025