e-Drug3D

1450

ELTROMBOPAG

INN
ELTROMBOPAG

cas 496775-61-2

CLASS

BLOOD
THROMBOPOIETIN RECEPTOR AGONIST (TPO)
THROMBOCYTOPENIA
CHRONIC IMMUNE (IDIOPATHIC) THROMBOCYTOPENIA (ITP)
INTERACTS WITH THE TRANSMEMBRANE DOMAIN OF THE HUMAN TPO-RECEPTOR AND INITIATES SIGNALING CASCADES THAT INDUCE PROLIFERATION AND DIFFERENTIATION OF MEGAKARYOCYTES FROM BONE MARROW PROGENITOR CELLS

ROUTE (list)

ORAL

ATC code

B02BX05

PK parameters

F 52 PERCENT
Tmax 4 HOUR
PPB 99 PERCENT
t1/2 26.5 HOUR

Solubility

PRACTICALLY INSOLUBLE IN AQUEOUS BUFFER ACROSS A PH RANGE OF 1 TO 7.4 AND IS SPARINGLY SOLUBLE IN WATER

Target

TARGET THROMBOPOIETIN

DrugCentral

Thrombopoietin receptor UNIPROT P40238 MPL

Download SDF file

[1,1'-Biphenyl]-3-carboxylic acid, 3'-[2-[(2Z)-1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy-

Formula:
C25H22N4O4

Calculated chemical properties:

MW 441.46
NB_atoms 33
XLogP 3.23
PSA 104.453
NB_HD 2
NB_HA 8
fsp3 0.12
Lipinski(0=no;1=yes) 1

FDA
NDA 022291 (label) INN (ELTROMBOPAG OLAMINE) PROMACTA (NOVARTIS) APPROVAL= AP YEAR= 2008
NDA 207027 (label) INN (ELTROMBOPAG OLAMINE) PROMACTA KIT (NOVARTIS) APPROVAL= AP YEAR= 2015
NDA 208815 (pdf not found) INN (ELTROMBOPAG) ELTROMBOPAG (ACTAVIS LABS FL INC) APPROVAL= TA YEAR= 2017
NDA 209938 (pdf not found) INN (ELTROMBOPAG) ELTROMBOPAG (TEVA PHARMS USA INC) APPROVAL= TA YEAR= 2018
NDA 216774 (label) INN (ELTROMBOPAG CHOLINE) ALVAIZ (TEVA PHARMS INC) APPROVAL= AP YEAR= 2023
NDA 212884 (pdf not found) INN (ELTROMBOPAG) ELTROMBOPAG (AMNEAL EU LTD) APPROVAL= TA YEAR= 2024
NDA 216620 (pdf not found) INN (ELTROMBOPAG OLAMINE) ELTROMBOPAG OLAMINE (ANNORA PHARMA) APPROVAL= AP YEAR= 2024
NDA 206788 (pdf not found) INN (ELTROMBOPAG OLAMINE) ELTROMBOPAG OLAMINE (HETERO LABS LTD V) APPROVAL= AP YEAR= 2025
NDA 219121 (pdf not found) INN (ELTROMBOPAG) ELTROMBOPAG (DR REDDYS LABS LTD) APPROVAL= TA YEAR= 2025
NDA 219638 (pdf not found) INN (ELTROMBOPAG OLAMINE) ELTROMBOPAG OLAMINE (SOMERSET THERAPEUTICS, LLC) APPROVAL= TA YEAR= 2025