e-Drug3D

1449

PLERIXAFOR

INN
PLERIXAFOR

cas 110078-46-1

CLASS

IMMUNOMODULATING
IMMUNOSTIMULANTS
HEMATOPOIETIC STEM CEL1 MOBILIZER
CXCR4 CHEMOKINE RECEPTOR INHIBITOR THAT BLOCKS BINDING OF ITS COGNATE LIGAND: STROMAL CELL-DERIVED FACTOR-LALPHA (SDF-1ALPHA)

ROUTE (list)

SUBCUTANEOUS

ATC code

L03AX16

PK parameters

VD 19.5 LITER (65 KILOGRAM)
Cl 3.3 LITER / HOUR (EQN)
PPB 58 PERCENT
t1/2 4 HOUR (0.24 MILLIGRAM / KILOGRAM)

Target

TARGET ALPHA-CHEMOKINE RECEPTOR CXCR4

PDB
8U4P (STRUCTURE OF AMD3100-BOUND CXCR4, GI COMPLEX)

Ligand code = VH6 (link to the list of PDB complexes)

Download experimental 3D coordinates of VH6 with added hydrogens

DrugCentral

C-X-C chemokine receptor type 4 UNIPROT P61073 CXCR4

Download SDF file

1,4,8,11-Tetraazacyclotetradecane, 1,1'-[1,4-phenylenebis(methylene)]bis-

Formula:
C28H54N8

Calculated chemical properties:

MW 502.79
NB_atoms 36
XLogP 0.42
PSA 89.265
NB_HD 6
NB_HA 8
fsp3 0.79
Lipinski(0=no;1=yes) 0

FDA
NDA 022311 (label) INN (PLERIXAFOR) MOZOBIL (GENZYME) APPROVAL= AP YEAR= 2008
NDA 205182 (pdf not found) INN (PLERIXAFOR) PLERIXAFOR (DR REDDYS) APPROVAL= AP YEAR= 2023
NDA 211901 (pdf not found) INN (PLERIXAFOR) PLERIXAFOR (MSN) APPROVAL= AP YEAR= 2023
NDA 213672 (pdf not found) INN (PLERIXAFOR) PLERIXAFOR (EUGIA PHARMA) APPROVAL= AP YEAR= 2023
NDA 215698 (pdf not found) INN (PLERIXAFOR) PLERIXAFOR (MEITHEAL) APPROVAL= AP YEAR= 2023
NDA 208980 (pdf not found) INN (PLERIXAFOR) PLERIXAFOR (ZYDUS PHARMS) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 205197 (pdf not found) INN (PLERIXAFOR) PLERIXAFOR (TEVA PHARMS USA INC) APPROVAL= AP YEAR= 2023
NDA 215334 (pdf not found) INN (PLERIXAFOR) PLERIXAFOR (AMNEAL) APPROVAL= AP YEAR= 2023
NDA 206644 (pdf not found) INN (PLERIXAFOR) PLERIXAFOR (GLAND) APPROVAL= AP YEAR= 2024
NDA 217560 (pdf not found) INN (PLERIXAFOR) PLERIXAFOR (HETERO LABS LTD VI) APPROVAL= AP YEAR= 2025