e-Drug3D

1443

cas 16506-27-7

CLASS

ANTINEOPLASTIC
ALKYLATING
CHRONIC LYMPHOCYTIC LEUKEMIA
INDOLENT B-CELL NON-HODGKIN’S LYMPHOMA (NHL)
FORM COVALENT BONDS WITH ELECTRON-RICH NUCLEOPHILIC MOIETIES RESULTING IN INTERSTRAND DNA CROSSLINKS

ROUTE (list)

INTRAVENOUS INJECTION IV

PK parameters

VD 25 LITER
Cl 42 LITER / HOUR
PPB 95 PERCENT
t1/2 0.4 HOUR (EQN)

MW 357.25
NB_atoms 23
XLogP 1.93
PSA 52.289
NB_HD 0
NB_HA 5
fsp3 0.50
Lipinski(0=no;1=yes) 1

FDA
NDA 022249 (pdf not found) INN (BENDAMUSTINE HYDROCHLORIDE) TREANDA (CEPHALON) APPROVAL= AP YEAR= 2008 NEWMOLECULARENTITY
NDA 022303 (pdf not found) INN (BENDAMUSTINE HYDROCHLORIDE) TREANDA (CEPHALON) APPROVAL= AP YEAR= 2008 NEWAPPLICATION
NDA 208194 (pdf not found) INN (BENDAMUSTINE HYDROCHLORIDE) BENDEKA (EAGLE PHARMS) APPROVAL= AP YEAR= 2015
NDA 205580 (pdf not found) INN (BENDAMUSTINE HYDROCHLORIDE) BELRAPZO (EAGLE PHARMS) APPROVAL= AP YEAR= 2018
NDA 204086 (pdf not found) INN (BENDAMUSTINE HYDROCHLORIDE) BENDAMUSTINE HYDROCHLORIDE (HOSPIRA INC) APPROVAL= TA YEAR= 2018
NDA 205476 (pdf not found) INN (BENDAMUSTINE HYDROCHLORIDE) BENDAMUSTINE HYDROCHLORIDE (INNOPHARMA LICENSING) APPROVAL= TA YEAR= 2018
NDA 210410 (pdf not found) INN (BENDAMUSTINE HYDROCHLORIDE) BENDAMUSTINE HYDROCHLORIDE (FRESENIUS KABI USA) APPROVAL= TA YEAR= 2018
NDA 204771 (pdf not found) INN (BENDAMUSTINE HYDROCHLORIDE) BENDAMUSTINE HYDROCHLORIDE (GLENMARK PHARMS LTD) APPROVAL= TA YEAR= 2019
NDA 209814 (pdf not found) INN (BENDAMUSTINE HYDROCHLORIDE) BENDAMUSTINE HYDROCHLORIDE (CELERITY PHARMS) APPROVAL= TA YEAR= 2019
NDA 215668 (pdf not found) INN (BENDAMUSTINE HYDROCHLORIDE) BENDAMUSTINE HYDROCHLORIDE (DR REDDYS LABS LTD) APPROVAL= TA YEAR= 2021
NDA 205574 (pdf not found) INN (BENDAMUSTINE HYDROCHLORIDE) BENDAMUSTINE HYDROCHLORIDE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2022
NDA 211530 (pdf not found) INN (BENDAMUSTINE HYDROCHLORIDE) BENDAMUSTINE HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 212209 (pdf not found) INN (BENDAMUSTINE HYDROCHLORIDE) VIVIMUSTA (AZURITY) APPROVAL= AP YEAR= 2022
NDA 205376 (pdf not found) INN (BENDAMUSTINE HYDROCHLORIDE) BENDAMUSTINE HYDROCHLORIDE (DR REDDYS) APPROVAL= AP YEAR= 2022
NDA 215033 (pdf not found) INN (BENDAMUSTINE HYDROCHLORIDE) BENDAMUSTINE HYDROCHLORIDE (APOTEX) APPROVAL= AP YEAR= 2022
NDA 216078 (pdf not found) INN (BENDAMUSTINE HYDROCHLORIDE) BENDAMUSTINE HYDROCHLORIDE (BAXTER HLTHCARE CORP) APPROVAL= AP YEAR= 2022
NDA 205447 (pdf not found) INN (BENDAMUSTINE HYDROCHLORIDE) BENDAMUSTINE HYDROCHLORIDE (BRECKENRIDGE) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 204230 (pdf not found) INN (BENDAMUSTINE HYDROCHLORIDE) BENDAMUSTINE HYDROCHLORIDE (APOTEX) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 204104 (pdf not found) INN (BENDAMUSTINE HYDROCHLORIDE) BENDAMUSTINE HYDROCHLORIDE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 206554 (pdf not found) INN (BENDAMUSTINE HYDROCHLORIDE) BENDAMUSTINE HYDROCHLORIDE (NANG KUANG PHARM CO) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 214739 (pdf not found) INN (BENDAMUSTINE HYDROCHLORIDE) BENDAMUSTINE HYDROCHLORIDE (EUGIA PHARMA) APPROVAL= AP YEAR= 2023
NDA 211001 (pdf not found) INN (BENDAMUSTINE HYDROCHLORIDE) BENDAMUSTINE HYDROCHLORIDE (MEITHEAL) APPROVAL= AP YEAR= 2023
NDA 219014 (pdf not found) INN (BENDAMUSTINE HYDROCHLORIDE) BENDAMUSTINE HYDROCHLORIDE (DR REDDYS) APPROVAL= AP YEAR= 2025 DISCONTINUED