e-Drug3D

1440

cas 62989-33-7

CLASS

METABOLISM
AGONIST
TREATMENT OF HYPERPHENYLALANINAEMIA (HPA)
REDUCTION OF PHENYLALANINE CONCENTRATION IN PATIENTS WITH PHENYLKETONURIA (PKU)
COFACTOR FOR THE ENZYME PHENYLALANINE HYDROXYLASE (PAH). TREATMENT WITH BH4 CAN ACTIVATE RESIDUAL PAH AND IMPROVE THE NORMAL OXIDATIVE METABOLISM OF PHE, AND DECREASE PHE LEVELS
TREATMENT OF TETRAHYDROBIOPTERIN (BH4) DEFICIENCY

ROUTE (list)

ORAL

PK parameters

Tmax 3.5 HOUR
VD 11433 LITER
Cl 1498 LITER / HOUR
PPB 32.7 PERCENT
t1/2 6.7 HOUR

TARGET PHENYLALANINE HYDROXYLASE

PDB
8XZN (CRYSTAL STRUCTURE OF FOLE RIBOSWITCH WITH BH4)

Ligand code = H4B (link to the list of PDB complexes)

Download experimental 3D coordinates of H4B with added hydrogens

MW 241.26
NB_atoms 17
XLogP -1.70
PSA 129.924
NB_HD 7
NB_HA 8
fsp3 0.56
Lipinski(0=no;1=yes) 0

FDA
NDA 022181 (pdf not found) INN (SAPROPTERIN DIHYDROCHLORIDE) KUVAN (BIOMARIN PHARM) APPROVAL= AP YEAR= 2007
NDA 205065 (pdf not found) INN (SAPROPTERIN DIHYDROCHLORIDE) KUVAN (BIOMARIN PHARM) APPROVAL= AP YEAR= 2013
NDA 207200 (pdf not found) INN (SAPROPTERIN DIHYDROCHLORIDE) SAPROPTERIN DIHYDROCHLORIDE (PH HEALTH) APPROVAL= AP YEAR= 2019
NDA 207207 (pdf not found) INN (SAPROPTERIN DIHYDROCHLORIDE) SAPROPTERIN DIHYDROCHLORIDE (PH HEALTH) APPROVAL= AP YEAR= 2019
NDA 210027 (pdf not found) INN (SAPROPTERIN DIHYDROCHLORIDE) SAPROPTERIN DIHYDROCHLORIDE (PH HEALTH) APPROVAL= AP YEAR= 2019
NDA 209452 (pdf not found) INN (SAPROPTERIN DIHYDROCHLORIDE) SAPROPTERIN DIHYDROCHLORIDE (DR REDDYS) APPROVAL= AP YEAR= 2021
NDA 207685 (pdf not found) INN (SAPROPTERIN DIHYDROCHLORIDE) SAPROPTERIN DIHYDROCHLORIDE (DR REDDYS) APPROVAL= AP YEAR= 2021
NDA 215798 (pdf not found) INN (SAPROPTERIN DIHYDROCHLORIDE) SAPROPTERIN DIHYDROCHLORIDE (DR REDDYS) APPROVAL= AP YEAR= 2022
NDA 215420 (pdf not found) INN (SAPROPTERIN DIHYDROCHLORIDE) SAPROPTERIN DIHYDROCHLORIDE (ANNORA PHARMA) APPROVAL= AP YEAR= 2022
NDA 215534 (pdf not found) INN (SAPROPTERIN DIHYDROCHLORIDE) SAPROPTERIN DIHYDROCHLORIDE (ANNORA PHARMA) APPROVAL= AP YEAR= 2022
NDA 216797 (pdf not found) INN (SAPROPTERIN DIHYDROCHLORIDE) SAPROPTERIN DIHYDROCHLORIDE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2025
NDA 218645 (pdf not found) INN (SAPROPTERIN DIHYDROCHLORIDE) ZELVYSIA (AUCTA) APPROVAL= AP YEAR= 2025
NDA 218797 (pdf not found) INN (SAPROPTERIN DIHYDROCHLORIDE) SAPROPTERIN DIHYDROCHLORIDE (ZENARA) APPROVAL= AP YEAR= 2025