e-Drug3D

1439

CLEVIDIPINE

INN
CLEVIDIPINE

cas 167221-71-8

CLASS

CARDIOVASCULAR
VASODILATOR
ANTIHYPERTENSIVE
DIHYDROPYRIDINE CALCIUM CHANNEL BLOCKER
REDUCTION OF BLOOD PRESSURE
THE CARBOXYLIC ACID METABOLITE IS INACTIVE AS AN ANTIHYPERTENSIVE

ROUTE (list)

INTRAVENOUS

ATC code

C08CA16

PK parameters

VD 11 LITER (65 KILOGRAM)
Cl 30.4 LITER / HOUR (EQN)
PPB 99.5 PERCENT
t1/2 0.25 HOUR

Solubility

PRACTICALLY INSOLUBLE IN WATER

Target

TARGET L-TYPE CALCIUM CHANNEL BLOCKER

DrugCentral

Voltage-dependent L-type calcium channel subunit alpha-1C UNIPROT Q13936 CACNA1C

Voltage-dependent L-type calcium channel subunit alpha-1D UNIPROT Q01668 CACNA1D

Download SDF file

3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, 3-methyl 5-[(1-oxobutoxy)methyl] ester

Formula:
C21H23Cl2NO6

Calculated chemical properties:

MW 456.30
NB_atoms 30
XLogP 4.25
PSA 85.32
NB_HD 1
NB_HA 7
fsp3 0.38
Lipinski(0=no;1=yes) 1

FDA
NDA 022156 (pdf not found) INN (CLEVIDIPINE) CLEVIPREX (CHIESI) APPROVAL= AP YEAR= 2008 NEWMOLECULARENTITY